AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
The current state of knowledge about the impact of selection on human genomic diversity is reviewed and conceptual advances in the understanding of human evolution over the past 10,000 years are highlighted.
The relative importance of genetic drift versus selection to evolutionary change has long been debated. This debate has mainly focused over long-time-scales (e.g. hundreds of thousands of generations), leaving the question of short-term evolutionary change relatively unaddressed. Our knowledge about the effects of sele...
The development of large genetic biobanks with deep phenotyping and whole-exome or whole-genome sequencing is enabling an ever-deeper understanding of human evolution. Here we review recent developments in two main research directions: 1) using the increasing sample sizes to infer extremely strong evolutionary constrai...
Genetics may help address the biodiversity crisis by providing information about genetic diversity and temporal changes in demography for species of interest. Advances in whole-genome sequencing create new opportunities for demographic analysis, even based on the two copies of a genome found in a single diploid individ...
Effective population size ( N e ) is a crucial parameter in the fields of evolutionary biology, conservation biology of endangered species, and selective breeding of domestic animals and crops, as it quantifies the magnitude of genetic drift and inbreeding occurring in a population. Because genetic drift is respon...
It is argued that population genetics provides the mathematical framework needed to extract evolutionary dynamics from cancer genomes and it is shown how models of mutation, selection and drift transform allele frequencies from descriptive measurements into quantitative estimates of clonal fitness and evolutionary timi...
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