TL;DR
In a rabbit osteoarthritis (OA) model, intra-articular administration of CRMH hydrogels achieved sustained drug retention and release within the joint cavity, and effectively promoted articular cartilage repair.
The developed bentonite-based nanocomposite hydrogel particle system represents a promising and effective platform for controlled delivery of chemotherapeutic agents in cancer therapy and shows enhanced, time-dependent anticancer activity compared to free Gemcitabine.
An injectable, self-healing hyaluronic acid/poly(ethylene glycol) composite hydrogel system may function as an EV-protective depot responsive to microenvironmental changes for localized therapeutic delivery.
As PNAG hydrogel particles demonstrated their potential for drug delivery, further studies could explore the tailoring of mesh sizes and broaden the spectrum of investigated biopharmaceuticals.
Poor aqueous solubility can limit drug release from biodegradable implants. We developed a multifunctional dual-jet electrospun drug-delivery system (DDS) designed to accelerate the release of poorly water-soluble bioactive substances. Its principle is based on introducing the drug-carrying matrix and release-rate modi...
Background: Diabetes-associated wound healing is frequently impaired due to persistent hyperglycemia, which causes vascular dysfunction and neuropathy, thereby delaying tissue repair. Objectives: In this study, hyaluronic acid and protamine nanoparticles (HA-PRO-NPs) were developed and optimized to encapsulate disulfir...
Biodegradable porous microspheres hold considerable promise as regenerative fillers, injectable biomaterials, tissue-engineering scaffolds, and drug-delivery carriers; however, how polymer properties and amphiphilic modification jointly influence pore formation remains insufficiently understood. In this study, porous m...
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