This study investigates the direct neuroprotective effects of scutellarin after ischemia–hypoxia, clarifies the relationship between upregulated CX3CR1 expression and neuronal apoptosis, and elucidates the mechanism by which scutellarin regulates apoptosis through the HIF‐1α–CX3CR1 axis.
Abstract
Stroke is a significant health threat characterized by high incidence, mortality, disability, recurrence, and complications. Over 70% of strokes are ischemic in nature. Reducing neuronal apoptosis following ischemic–hypoxic injury is crucial for effective treatment. This study investigates the direct neuroprotective effects of scutellarin after ischemia–hypoxia, clarifies the relationship between upregulated CX3CR1 expression and neuronal apoptosis, and elucidates the mechanism by which scutellarin regulates apoptosis through the HIF‐1α–CX3CR1 axis. This research provides a robust theoretical foundation for the clinical application of scutellarin in the management of ischemic stroke.
This work demonstrated that recombinant CXCL16 (rCXCL16) modulated the expression of inflammation- and repair-associated markers in primary microglia and in the ischemic brain and suggested that its neuroprotective effects are associated with reduced inflammatory marker expression and attenuation of apoptotic injury af...
Hong-Yi Sun, Cheng Zhou, Jing Hu et al.· Scientific Reports· 0 citations
Ischemic stroke (IS) remains a devastating cerebrovascular disease associated with high morbidity, mortality, and disability, while effective restorative therapies remain limited, highlighting an urgent unmet clinical need. Post-stroke angiogenesis contributes to vascular remodeling, restoration of cerebral blood flow,...
Long-Rui Wang, Sen Zhang, Cheng-Di Liu et al.· Brain Research Bulletin· 0 citations
Ischemic stroke remains a leading cause of mortality and disability worldwide, yet current therapeutic strategies, such as thrombolysis and thrombectomy, are constrained by narrow treatment windows and incomplete microvascular repair. While angiogenesis is pivotal for long-term functional recovery, the epigenetic mecha...
Tian-Qing Xiong, Meng-Qi Zhang, Ping Sun et al.· Brain : a journal of neurolo...· 0 citations
Cerebral ischemic stroke (CIS) is characterized by high morbidity, disability, and mortality, representing a major global public health challenge and imposing a substantial social and economic burden worldwide. Cerebral ischemia/reperfusion (I/R) triggers complex pathological cascades, resulting in secondary brain inju...
Bei-Bei Chen, Yu-Han Zhang, Cheng-Fang Zhai et al.· Pharmacology and Therapeutic...· 0 citations
It is suggested that HIF-1α may serve as a molecular link between ischemic injury, ferroptosis, and endogenous repair responses and therapeutic strategies that selectively modulate HIF-1α signaling according to the stage and pathological context of ischemic stroke may provide a more rational approach to limiting ferrop...
Mao-Mei Song, Jian-Ming Wang, Xiao-Feng Li et al.· Frontiers in Neurology· 0 citations
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