Therapeutic potential of apigenin in neurodegenerative diseases and brain health

Medicinal Plants and Bioactive Phytochemicals Targeting Neuroinflammation: Molecular Mechanisms, Preclinical Evidence and Translational Challenges

Neuroinflammation is the inflammatory response within the central nervous system which is linked to many neurological disoders. These disorders include Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, ischemic stroke, among others. Short-term reaction to inflammation within the central nervous system has a...

Postbiotics as a therapeutic frontier in Parkinson’s disease: Insights into molecular pathways and neuroprotective effects

Plant-Derived Bioactive Compounds in Aging: Shared Mechanism Linking Cardiovascular and Neurodegenerative Diseases

Population aging is a major global demographic shift associated with an increased prevalence of chronic non-communicable diseases, particularly cardiovascular and neurodegenerative disorders. These conditions share common pathophysiological mechanisms, including oxidative stress, chronic inflammation, and impaired cell...

Role of arbutin and acetoside against Parkinson’s disease

Parkinson’s disease (PD) is an incurable progressive neurodegenerative condition, which is characterized by a selective loss of dopaminergic neurons in the substantia nigra and subsequent development of motor impairment along with a non-motoric syndrome. It has a multifactorial etiopathogenesis, including oxidative str...

Hesperidin as a Neuroprotective Agent in Parkinson’s Disease: Mechanistic Insights and In Silico Validation

Combined in silico and experimental findings highlight hesperidin’s strong binding to key molecular targets, whereas experimental evidence also confirms its antioxidant, anti-inflammatory, and anti-apoptotic effects, supporting its potential as a disease-modifying candidate in PD therapy.

Repurposing Antidiabetic Drugs in Neurodegenerative Disorders: From Preclinical Mechanisms to Clinical Evidence