LncRNA PCAT7 drives tumorigenesis and glycolytic reprogramming in breast cancer via the ceRNA-mediated miR-204-5p/RUNX2 axis

Integrative Pan‐Cancer Characterization of lncRNA UPK1A‐AS1 and Its Role in Hypoxia‐Associated Sorafenib Resistance in Hepatocellular Carcinoma

It is suggested that UPK1A-AS1 is a hypoxia‐inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type‐dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia‐associated drug resistance in HCC.

METTL3-m6A-IGF2BP2 Axis-Mediated Stabilization of MTFR1 Promotes Glycolytic Reprogramming in Colorectal Cancer.

BACKGROUND Metabolic reprogramming fuels colorectal cancer (CRC), yet upstream regulators that lock cells into a glycolytic state remain incompletely defined. METHODS We integrated single-cell and spatial transcriptomics with GWAS-eQTL-Mendelian randomization to nominate CRC-associated candidate genes, and profiled t...

NAT10 promotes prostate cancer progression by acetylating mRNA of MARK2 and activating mTOR/HIF-1α/C-Myc pathway to enhance glycolytic reprogramming.

miR-139-5p Targets CENPM to Suppress EMT and Malignant Progression of Hepatocellular Carcinoma via Regulating the Akt/mTOR Pathway and β-Catenin Nuclear Translocation

Purpose This study aims to screen key miRNA/mRNA axes associated with hepatocellular carcinoma (HCC), and then conduct functional validation and mechanistic exploration, thereby offering novel clues for screening HCC-targeted therapeutic candidates. Methods Bioinformatics analysis was performed to identify key HCC-rela...

PHB2 Promotes Glycolytic Reprogramming in Triple-Negative Breast Cancer Through FOXM1-Dependent Activation of LDHB.

Triple-negative breast cancer (TNBC) presents significant clinical challenges due to its aggressive phenotype and the limited availability of molecularly targeted therapies. In this study, we investigated the therapeutic potential of targeting PHB2 in TNBC by combining bioinformatics analysis with comprehensive in vitr...

THAP7-AS1 sponges miR-4286 to upregulate PFKFB2, accelerating aerobic glycolysis and aggravating liver cancer progression

Background Liver cancer ranks among the most prevalent and deadliest malignancies worldwide. As one of the largest metabolic organs, the liver undergoes profound metabolic reprogramming, encompassing oxidative phosphorylation and aerobic glycolysis (the Warburg effect)-a hallmark of liver cancer progression that drives...