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AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Open access
Sep 2026
Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters
Overall, these results recast Piezo1 mechanotransduction from isolated-channel force sensing to a membrane-driven self-organization process that spatially biases force-dependent calcium signaling within cells.
Zi-Xian Guo, Amrit Bagchi, Monika Dhankhar et al.
· bioRxiv · 0 citations
Review
Open access
Sep 2026
Ventral cytoskeletal remodeling as a mechanism for oscillatory load-induced Piezo1 overactivation and cancer cell vulnerability
A unified mechanobiological framework describing how frequency-dependent remodeling of the ventral cytoskeleton regulates Piezo1 activity in mesenchymal-like cancer cells is presented, demonstrating that the response to oscillatory mechanical stimulation depends on the interplay between loading parameters and the dynam...
Ivana Pajić-Lijaković, M. Milivojević, B. Martinac et al.
· Biophysical Reviews · 1 citation
Review
Open access
Aug 2026
Soft tissue mechanosensing and remodeling: the core regulatory role of Piezo/TRPV4 ion channels
A multiscale framework that spans from molecular mechanisms to organ-level physiology and focuses on the directly mechanosensitive Piezo1/2 channels and the mechano-responsive TRPV4 channel is developed, drawing on their distinct molecular architectures to ground divergent gating properties.
Xuan Fan, Ming-Wei Shi, Zhen Wang et al.
· Frontiers in Cell and Develo... · 0 citations
Open access
Aug 2026
Structural basis of the gating mechanism of the large-conductance mechanosensitive channel from Escherichia coli
Three cryo-EM structures of EcMscL in two different lipid environments and two distinct conformational states are solved; closed and open-like, guided by EPR.
Katie Hardman, Joshua L. Wort, Qaiser Waheed et al.
· Nature Communications · 1 citation
Review
Aug 2026
Reciprocal Coupling among Extracellular Matrix Mechanics, Mechanosensitive Ion Channels, and Cell Remodeling Behaviors.
This review discusses the close interplay among ECM mechanics, mechanosensitive ion channels, and cell remodeling behaviors, with particular emphasis on ion channels as mechanochemical control nodes that connect material-defined mechanical cues to cytoskeletal tension, adhesion dynamics, and transcriptional reprogrammi...
Zhanshuo Cao, Bo-Ying Li, Liang Qiu et al.
· ACS Applied Materials and In... · 0 citations
Review
Open access
Sep 2026
Decoding Cytoskeletal Mechanobiology with Tunable Microenvironments
This review surveys major classes of tunable platforms used to study cytoskeletal dynamics, including biologically derived matrices, synthetic hydrogels, micropatterned and nanotopographic substrates, and polymeric thin films, highlighting how each approach affords unique insight into cytoskeletal regulation.
Rupesh Kandel, Amzadul Hoque Chowdhury, Jacqueline Robinson et al.
· ACS Biomaterials Science & E... · 0 citations