TL;DR
SUVRc for [11C]PiB PET enables more accurate quantification of A{beta} burden than SUVR in cross-sectional and longitudinal studies (relative to SRTM DVR), while enabling imaging at earlier and shorter time-windows.
The findings highlight the importance of considering cut-point uncertainty and methodological influences when interpreting early-stage amyloidosis and highlight the importance of considering cut-point uncertainty and methodological influences when interpreting early-stage amyloidosis.
Cerebellar cortical Aβ deposition raises WC reference signals and interferes with CL-based 18F-Florbetapir Aβ PET quantification, which systematically underestimates true cerebral Aβ burden.
PURPOSE This study aimed to (i) compare TotalSegmentator Fast and Normal inference modes on low-dose PET/CT, (ii) evaluate whether CT denoising improves segmentation longitudinal consistency, and (iii) examine whether the selected pipeline can capture long-term within-participant volumetric trends over approximately 13...
High-resolution dhPET revealed significantly higher SUVRs in Aβ⁺ compared with Aβ⁻ subjects in supratentorial structures, including cerebral white matter, and in cerebellar gray matter.
Across regions and networks, SEOT performed similarly or better than tau load in predicting metabolic dysfunction and may improve diagnostic characterisation and prediction of cognitive impairment beyond [18F]FDG-PET.
The proposed framework enables non-invasive Aβ mapping using a clinically feasible MRI protocol and may support repeated assessment for monitoring during anti-amyloid treatment.
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