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Open access Aug 2026

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer. F7 was highly expressed in tumor tissues and closely associ...

Lei Gao, Qin-Ying Han, Yunpeng Wang et al. · 0 citations
Review Sep 2026

SET Oncoprotein in Gastric Cancer: A Master Regulator of PP2A Suppression and Tumor Progression

Therapeutic modulation of the SET-PP2A axis may provide a novel strategy for suppressing tumor progression and improving treatment outcomes, and further mechanistic studies and welldesigned clinical investigations are required to establish the therapeutic relevance of SET targeting and facilitate its integration into p...

Rohit Das, Shikha Yadav, Sudeshna Das et al. · 0 citations
Aug 2026

THBS1 Targets Tumor‐Associated Macrophages to Regulate Gastric Cancer Peritoneal Metastasis via Metabolic Reprogramming

Thrombospondin 1 regulates pathological interorgan communication between GC cells and the peritoneal niche by targeting TAMs through metabolic reprogramming, thereby providing a potential therapeutic target for GC with PM and insights into interorgan metastasis mechanisms.

Zheyu Song, Yuan-Yu Wu · 0 citations
Aug 2026

COL1A1 modulates apatinib sensitivity through promoting glycolysis and angiogenesis in gastric cancer cells.

BACKGROUND Our previous bioinformatic study identified Collagen type I alpha 1 chain (COL1A1) as a candidate regulator associated with gastric cancer (GC) progression and response to anti-angiogenic therapy. However, whether COL1A1 influences the sensitivity of GC cells to apatinib and the underlying mechanisms remains...

Yaxing Liu, Ying-Ying Chen, Su-Hui Zhou et al. · 0 citations

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