Metabolic reprogramming in pancreatic cancer: interplay of glucose, lipid, and amino acid metabolism in tumor progression

Cancer Metabolism: Recent Advances in Biochemical Mechanisms and Targeted Therapeutic Strategies

Background: Cancer is characterized not only by genetic and epigenetic abnormalities but also by profound alterations in cellular metabolism. Metabolic reprogramming enables malignant cells to meet the increased requirements for energy production, biosynthesis, redox regulation, proliferation, invasion, and adaptation...

Research progress on lactate metabolism in lung cancer: Tumorigenesis, drug resistance and clinical translation (Review)

Therapeutic resistance is the main obstacle to long-term survival in lung cancer, with metabolic reprogramming identified as a key factor in this failure. Accumulating evidence suggests that metabolic reprogramming, particularly the aberrant metabolism of lactate, plays a crucial role in the progression of lung cancer...

Lipid metabolic reprogramming in ovarian cancer: molecular mechanisms and therapeutic implications.

Targeting metabolic reprogramming in cancer: Past, present, and future.

Cancer cells undergo profound metabolic reprogramming to sustain uncontrolled proliferation within a nutrient-limited and often hypoxic tumor microenvironment (TME). Metabolic rewiring is an active driver of oncogenesis, immune evasion, epigenetic remodeling, and therapy resistance. Over the past century, our understan...

Lipid Metabolic Reprogramming in Colorectal Cancer: A Central Hub Integrating Diet, Microenvironment, and Therapy Resistance.

Colorectal cancer (CRC), a significant malignancy of the digestive system, represents a considerable threat to global health. Currently, its clinical efficacy is often limited by tumor heterogeneity and therapeutic resistance. Lipid metabolic reprogramming has been identified as a core process in CRC, not only providin...

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer stem cells (CSCs) are increasingly recognized as metabolically plastic subpopulations within malignant tissues that drive tumor initiation, metastatic dissemination, and relapse after therapy. Although traditional models of cancer metabolism have emphasized aerobic glycolysis, CSCs rarely exhibit a single, clear...