TL;DR
WNK4 acts as an immune-relevant suppressor in endometrial cancer, partly by limiting M2-like polarization and weakening macrophage-driven tumor support, partly by limiting M2-like polarization and weakening macrophage-driven tumor support.
Thrombospondin 1 regulates pathological interorgan communication between GC cells and the peritoneal niche by targeting TAMs through metabolic reprogramming, thereby providing a potential therapeutic target for GC with PM and insights into interorgan metastasis mechanisms.
Background Lipid metabolic reprogramming is increasingly recognized as a driver of breast cancer progression; however, how lipid metabolism-associated risk states are translated into immune remodeling and epithelial–mesenchymal transition (EMT) remains unclear. This study aimed to identify a lipid metabolism-related re...
The tumor microenvironment plays a critical role in osteosarcoma (OS) progression. However, the mechanisms underlying intercellular communication remain incompletely understood. This study aimed to investigate the role of the APP-CD74 signaling axis in OS and its impact on tumor progression and immune remodeling. Integ...
The PLK1/FOXM1-associated tumor-cell state may represent a distinct molecular feature associated with proliferative activity, invasive phenotypes, and macrophage-related immune features in EC and is highlighted in potential therapeutic directions for future investigation.
Background Cancer-associated fibroblasts (CAFs) foster an immunosuppressive tumor microenvironment (TME) and confer resistance to immune checkpoint blockade (ICB) in gastric cancer (GC). However, the mechanisms by which specific CAF subsets regulate metabolic crosstalk and immune evasion remain poorly defined. Methods...
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