It seems that several genes that are not directly related with hormone metabolism and basic signal transduction pathways might have an important role in relapse and disease progression and, thus, can be targeted for new treatment approaches for breast cancer.
The CDRS performed well in predicting patient outcomes and showed strong prognostic validity, and differences in pathways enrichment, immune infiltration, drug sensitivity, and other factors between high risk and low risk groups based on CDRS scores were observed.
Yi-Yang Lu, Hao Chen, Rui-Yan Mei et al.· Discover Oncology· 0 citations
Objective: Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that greatly influence breast cancer progression. In this study, we used in silico analysis to determine the potential pathways and genes that could affect breast cancer progression associated with CAFs.Method: Data fr...
Nail Beşli, N. Ercin, B. Sarikamis-Johnson et al.· Interdisciplinary Medical Jo...· 0 citations
It is found that cancer stem cell phenotypes such as chemoresistance, metastasis and self-renewal are conserved across patients, but arise from largely patient-specific gene and isoform programs.
Matthew S. Jung, Lindsey J. Davis, Audrey A. Birdwell et al.· bioRxiv· 0 citations
It is demonstrated that treatment with the mTOR inhibitor rapamycin and the FDA-approved rapamycin analog everolimus effectively suppressed miR-1290-induced TNBC cell proliferation, suggesting a potential therapeutic strategy for TNBC.
Jinkwon Lee, Taesang Son, Gyeonghwa Kim et al.· Signal Transduction and Targ...· 0 citations
This study identifies ZUP1 as a potential oncogenic factor and a robust independent prognostic biomarker in breast cancer and suggests that ZUP1 is a novel multifaceted biomarker with significant implications for personalized treatment strategies in breast cancer.
