TL;DR
Early-onset CMA presented with different demographic and disease characteristics and treatment patterns than later-onset disease, and survival of early-onset CMA was higher than later-onset CMA.
EO-SBNETs represent a rising and clinically distinct subgroup characterized by similar presentation and treatment but relatively favorable long-term outcomes compared with AO-SBNETs, suggesting potential biological differences warranting further investigation.
INTRODUCTION The global rise in early-onset colorectal cancer (EORC) contrasts with declining rates in older adults, suggesting emerging environmental and biological influences. Data from non-Western populations, particularly India, remain scarce despite a young demographic and distinct tumor biology. METHODS A retro...
Overall, EOPC demonstrated a distinct clinicopathological phenotype characterized by more aggressive pathological features and advanced nodal disease, emphasizing the need for age-specific pancreatic cancer management.
Background/Aims Hepatocellular carcinoma (HCC) in younger patients is uncommon, and its clinical behavior and prognosis remain unclear. We aimed to evaluate the characteristics, treatment patterns, and outcomes of young-onset HCC using large-scale datasets. Methods This study analyzed two cohorts: the Asan Medical Ce...
Findings indicate that youth does not confer prognostic advantage and support the need for targeted prevention, earlier recognition and tailored research efforts focused on gastric cancer in younger populations.
INTRODUCTION Young-onset renal cell carcinoma (RCC) exhibits distinct clinicopathologic features. We retrospectively compared outcomes and survival dynamics between young- and older-onset RCC cohorts. PATIENTS AND METHODS We included RCC patients undergoing partial or radical nephrectomy (2015-2024), categorized as y...
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