Polycyclic aromatic hydrocarbons exposure and hyperuricemia: insights from China-Northern Anhui Coal workers Cohort study to network toxicology analysis

Association of Combined Exposure to Polycyclic Aromatic Hydrocarbons, BTX and Metals with Metabolic Syndrome Risk.

Mixed exposure to PAHs, BTX, and metals increased MetS risk more than single pollutants, highlighting their importance for future occupational health monitoring and risk management.

Occupational exposure to polycyclic aromatic hydrocarbons and the risk of upper gastrointestinal cancers: a systematic review and meta-analysis of cohort studies.

Occupational PAH exposure is modestly associated with upper gastrointestinal cancer risk, particularly esophageal cancer, with higher risk estimates observed in high-exposure occupations.

The association between carbon monoxide and cardiovascular-kidney-metabolic syndrome in the Chinese populations: China Health and Retirement Longitudinal Study.

Arsenic species and lipid metabolism under low-to-moderate arsenic exposure: evidence from NHANES and a Chinese adult population

The relationship between low-to-moderate arsenic exposure and lipid metabolism remains unclear, particularly for different urinary arsenic species and the potential role of urinary albumin-to-creatinine ratio (UACR). This cross-sectional study used NHANES 2009–2020 data and an adult population from Zhaodong, China. The NHANES analysis included 2,104 participants, representing 52,612,536 adults, and the Zhaodong analysis included 310 participants. Creatinine-adjusted urinary total arsenic (UTA) and dimethylarsinic acid (DMA) were designated as the principal exposure indicators, whereas monomethylarsonic acid (MMA), arsenite (As III ), and arsenate (As V ) were evaluated in supplementary exploratory analyses. Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and UACR were examined as outcomes. Multivariable regression, restricted cubic spline, subgroup, and mediation analyses were performed. The median UTA concentrations were 3.73 μg/L in NHANES and 12.37 μg/L in the Zhaodong population. In NHANES, after multivariable adjustment, UTA and DMA were positively associated with LDL-C levels, with β values of 0.68 and 0.85, respectively, and both associations remained significant after FDR correction ( q < 0.1). Restricted cubic spline analyses revealed a nonlinear association between DMA and LDL-C. In the Zhaodong population, the highest quartile of DMA was associated with lower odds of abnormal LDL-C compared with the lowest quartile. In NHANES, both UTA and DMA were positively associated with UACR. Mediation analyses did not support a meaningful mediating role of UACR, although small negative indirect effects were observed in the LDL-C models involving UTA and DMA. Supplementary exploratory analyses involving MMA, As III , and As V yielded several nominal associations. Low-to-moderate urinary arsenic exposure may be associated with altered LDL-C levels and increased UACR, with species- and population-specific differences. The mediation analyses did not support a meaningful mediating role of UACR. Prospective studies are needed to confirm these findings.

A Cross-Sectional Study on Immune-Inflammatory Responses: Exposure to Polycyclic Aromatic Hydrocarbons Alters Pteridine Metabolism and Activates the Kynurenine Pathway

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants generated from the incomplete combustion of organic materials and represent an important source of occupational and environmental exposure. Aside from their carcinogenic properties, PAHs are known to exert immunomodulatory and proinflammatory effects. Immune activation is closely associated with alterations in pteridine metabolism and activation of the kynurenine pathway; however, evidence linking PAH exposure to these immune-inflammatory pathways in humans remains limited. This study aimed to investigate the systemic biological effects of occupational exposure to PAHs from asphalt fumes in road construction workers, with a particular focus on alterations in pteridine metabolism and activation of the kynurenine pathway, using a combined panel of exposure and mechanistic biomarkers. Routine clinical parameters remained within normal ranges while urinary 1-hydroxypyrene, a well-established biomarker of internal PAH exposure, was significantly elevated, confirming substantial PAH exposure. Key findings revealed profound alterations in two critical metabolic pathways: (i) Pteridine metabolism was shifted, with increased neopterin and decreased biopterin levels, indicating activation of cell-mediated immunity and reduced cofactor availability; (ii) the kynurenine pathway was concurrently activated, as reflected by elevated kynurenine, reduced tryptophan, and increased estimated indoleamine 2,3-dioxygenase activity. These findings indicate that low-level but chronic PAH exposure induces sustained Th1-type immune activation and metabolic disturbances in the absence of overt clinical pathology, representing a state of subclinical biological adaptation.

Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome –wide association study