Revealing the Link Between Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Stroke: A Comprehensive Epidemiological and Network Toxicology Perspective
PFAS exposure, particularly PFOS-dominated mixtures, may represent an environmental correlate of stroke risk, with lipid dysregulation potentially contributing to this association.
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants linked to various diseases, yet their association with arterial stiffness remains unclear. Using data from 5209 U.S. adults in the National Health and Nutrition Examination Survey (2011-2018), the association between PFAS exposure and...
De-Xiang Xia, Rui Li, Chang Shu et al.· Ecotoxicology and Environmen...· 0 citations
It is suggested that mixed PFAS exposure, particularly to PFOA and PFHpA, may induce impaired renal function, with increased blood lipids playing an important mediating role.
Dandan Xu, Z. Mo, Jie Xiang et al.· Environmental Pollution· 0 citations
Per- and polyfluoroalkyl substances (PFAS) are recognized endocrine disruptors; however, evidence on PFAS mixture effects, exposure thresholds, and mechanisms of thyroid disruption in Chinese populations remains limited. In this cross-sectional study, 22 serum PFAS congeners were quantified by ultra-high-performance li...
Shu-Ting Wang, Xue-Zhen Zhao, Zhong-Xue Zhao et al.· Food and Chemical Toxicology· 0 citations
Per- and polyfluoroalkyl substances (PFAS) are a class of neurotoxic persistent organic pollutants that may increase the risk of cognitive impairment and dementia, yet their association with schizophrenia (SCZ) remains unclear. This study aimed to investigate the relationship between plasma PFAS levels and the risk of...
Xu-Lu Gao, Tian-Xian Wang, Yu-Yu He et al.· Ecotoxicology and Environmen...· 0 citations
BACKGROUND
Evidence regarding the association between per- and polyfluoroalkyl substances (PFAS) and metabolic syndrome (MetS) across adult subgroups remains limited. This study aimed to examine PFAS exposure and MetS risk in adults, focusing on potential susceptibility factors.
METHODS
We searched PubMed, CINAHL, Em...
Ying-Hao Su, Wei-Chun Lin, Kuan-Wen Wu et al.· Ecotoxicology and Environmen...· 0 citations
The findings suggest that exposure to low levels of some alternative and precursor PFAS may be widespread in Canada and reinforce the role of pregnancy and breastfeeding as excretion pathways for legacy PFAS and support previous investigations demonstrating that exposure to some PFAS may be lower amongst financially di...
M. Borghese, Rebecca Lelievre, Sara Packull-McCormick et al.· Environmental Health· 0 citations
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