This integrative analysis prioritizes ACSL1, EPM2AIP1, MALT1, and RASGRP3 as candidate genes connecting fatty acid metabolic dysregulation with AD-associated neuroinflammatory processes, and supports a prioritized candidate framework for future functional testing.
Multi-omics analyses indicate that, in primary pre-transplant HCC, post-transplant recurrence is associated with an imbalance between a higher estimated Δ6-desaturation index and attenuated oxidative catabolism-related features of linoleic acid, accompanied by Treg-associated immunosuppressive remodeling.
Ruixin Zhang, Anhong Zhang, Tian Gao et al.· Frontiers in Immunology· 0 citations
PTZ-induced kindling was associated with marked plasma metabolic alterations involving amino acid-, tryptophan-, and lipid-related pathways, which supports the broader relevance of metabolic dysregulation to epilepsy, while the mechanistic roles and biomarker potential of individual metabolites require independent vali...
Juan Ren, Fu-Li Wang, Zi-Jian Li et al.· Frontiers in Neuroscience· 0 citations
Disrupted immune balance and neuroglial–vascular cell homeostasis in vascular dementia is revealed, and ELF2 is prioritized as a candidate regulator associated with immune heterogeneity in VaD.
Li Liang, Cui-Qin Shen, Shi-Ren Huang et al.· Medicine· 0 citations
The important role of macrophage-associated nucleotide metabolism in HTS is revealed and NCF1 and GPR34 are identified as potential biomarkers and therapeutic targets.
Qiyun Luo, Xia Yang, Jiang-Yong Shen et al.· Journal of Burn Care & Resea...· 0 citations
Parkinson's disease (PD) is a major neurodegenerative disorder after Alzheimer's disease, yet the molecular alterations driving its onset and progression remain only partly understood. Although mannose metabolism has been linked to nervous-system dysfunction, its contribution to PD has not been clearly defined. This...
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular and metabolic heterogeneity associated with distinct phenotypic states. However, the contribution of transcription factor (TF)-driven regulatory programs to metabolic subtype stratification remains poorly understood. This study aims to determine wh...
Jie Ke, Shuai Liu, Jun-Ming Xu et al.· Frontiers in Oncology· 0 citations
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