Open access
Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease
A. Shvetcov
Shannon Thomson
Mark E. Graham
Brittany M. Hauger
Jessica E. Keller
Christine J. Smoyer
S. Tague
Ann-Na Cho
Farhad B. Imam
V. Krish
Matthew K. Taylor
Jonathan Mahnken
Debra K. Sullivan
Joanne H. Reed
Jeffrey M. Burns
Chad Slawson
R. Swerdlow
Heather M. Wilkins
C. Finney
Medicine
Abstract
Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood.