TL;DR
A-Zr phyto-nanohybrids synthesized via a green method exhibit significant hepatoprotective potential against CCl₄-induced liver injury, supporting their role as a sustainable nanomedicinal strategy for chemically induced hepatotoxicity.
Hepatorenal toxicity stems from chronic oxidative stress (OS) generated from mechanisms underlying chemical or metabolic injury. The present study investigates the hepatorenal toxicity induced by carbon tetrachloride (CCl4) and alloxan, and the hepatorenal-protective potential of Berberine-loaded (BBR) silver–zinc oxid...
Results indicate that BA- NPs prepared by Span 60/Tween 80 emulsification provide potent hepatoprotection against paracetamol- induced liver injury through synergistic, multi- mechanistic action, significantly protecting against hepatic injury by concurrently suppressing oxidative stress, inflammatory signaling pathway...
This study provides the first demonstration that asiatic acid exerts robust systemic antioxidative, hepatoprotective, and neuroprotective effects against CPF-induced toxicity, highlighting AA’s therapeutic potential for mitigating organophosphate pesticide poisoning.
It is demonstrated that radiation-synthesized gallotannin hydrogel (GTH) exerts nephroprotective effects against ATO-induced nephrotoxicity, driven by antioxidant, anti-inflammatory, and anti-apoptotic mechanisms mediated via modulation of the miR-223/TXNIP axis.
Cinnamic acid may exert hepatoprotective effects against CCl₄-induced liver injury, with secondary favorable effects on renal biochemical markers of CCl₄-induced systemic toxicity, by modulating oxidative and inflammatory pathways.
It is suggested that the developed Polyherbal combination (2:1:1) and its prepared nanoparticles exhibit chemopreventive effects against HCC and could be used as adjuvant therapy.
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