Aug 2026· Zeitschrift für Induktive Abstammungs- und Vererbungslehre· Vol 301· 0 citations· 50 references
Medicine
TL;DR
Each isoform was assigned a cytoplasmic–nuclear relative concentration index (CN-RCI) measured from ENCODE subcellular fractionation RNA-seq across 15 human cell lines, and masked genes with both tissue-dominant isoforms localized were identified.
This work presents a robust RNA FISH protocol for detecting the lncRNA Xist, a chromatin-associated master regulator of X chromosome inactivation (XCI) that serves as a paradigm for lncRNA biology and demonstrates the effectiveness of this method for investigating lncRNA localization and chromatin-associated function.
Hye-Rim Shin, Hyun-jung Oh· Methods in molecular biology· 0 citations
This study establishes a map of cellular-context-dependent genetic regulation of lncRNAs in the human brain, providing a basis for nominating lncRNAs with potential roles in mediating genetic risk for brain disorders.
Yu-Ran Jia, Li Chen, Li-Yang Song et al.· Nature Communications· 0 citations
A cross-tissue single-cell long-read isoform atlas spanning 26 human tissues is presented and it is demonstrated that isoform usage is a structured, measurable axis of cellular identity that is distinct from gene expression.
Madhav Mantri, A. Detweiler, Jaeyoon Lee et al.· bioRxiv· 0 citations
Sex-associated differences in hippocampal function are well-recognized, yet the molecular mechanisms underlying these variations remain incompletely understood. In the CA1 region, the spatial organization of the transcriptome between the soma and neuropil supports local mRNA translation, a mechanism essential for...
J. P. Silva, J. Catalán, F. Olave et al.· Biology of Sex Differences· 0 citations
These experiments and modeling suggest that the process of local translation at the OMM is kinetically controlled by the cell, and reveal an unappreciated mechanism by which active transport of RNAs enables cells to modulate their translation within minutes through RNA localization control.
Surbhi Sharma, Xue-Mei Wang, Steven Nguyen et al.· bioRxiv· 0 citations
This work has developed RADIS (Reactivity Analysis of Deep and Intergenic RNA Structure), a strategy that yields strand-resolved chemical probing reactivity profiles across entire intron-rich loci by creating tiled arrays of RNAs that comprehensively span long genomic distances.
Claire Fleurisson, Si-Jin Chen, Ryan M. Macdonald et al.· bioRxiv· 0 citations
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