TL;DR
A three-factor, three-level Box–Behnken Design-optimized Wogonin-NL constitutes a physico-chemically well-defined, biologically active nanoliposomal platform with cancer-preferential cytotoxicity and a validated stability profile.
The developed nanoliposomal system offers significant clinical advantages including potential for enhanced tumor targeting, reduced dosing frequency, and minimized systemic toxicity, pending in vivo validation, and improved therapeutic outcomes.
The developed nanoemulsion effectively addressed the major biopharmaceutical limitations of apigenin by improving its solubility, intracellular delivery, and antioxidant efficacy and establish A-NE as a stable and efficient nanocarrier platform with considerable potential for advanced intracellular antioxidant therapy.
Objective: To formulate and evaluate palbociclib-loaded nanosponges (PB-NSPs) as a controlled drug delivery system to improve the solubility, stability, and release behavior of palbociclib for cancer therapy. Methods: PB-NSPs were prepared using β-cyclodextrin (β-CD) and characterized for particle size, zeta potential,...
Background: Trans-resveratrol (3,5,4′-trihydroxystilbene) is a natural polyphenolic antioxidant widely used in anti-aging dermocosmetics for its strong radical-scavenging capacity and its activation of cell-protective pathways such as sirtuin 1 (SIRT1). However, its poor aqueous solubility, photochemical lability, and...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
