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Tumor-Targeted Delivery of Curcumin via Hyaluronic Acid-Functionalized Polymeric Nanoparticles: Characterization and Mechanistic Insights into PI3K/AKT/mTOR Signaling

Xinyao Du Song Xu Fei Xu Qiao Liu Feng-Ning Wang Xiaoli Deng Yujiao Yang Feng Yang Qingyang Yao L. Zou Wanning Wang Mijia Yuan T. Zhong P. Huang
Aug 2026 · BioNanoScience · Vol 16 · 0 citations · 32 references

TL;DR

The promise of hyaluronic acid-based polymeric nanoparticles as a powerful nanoplatform to improve curcumin delivery and maximize anticancer effects by modulating key intracellular signaling pathways is highlighted, offering a strategy to overcome its biopharmaceutical limitations.

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