Aug 2026· Clinical Ophthalmology· Vol 20· 0 citations· 23 references
Medicine
TL;DR
The CNA0T0 IOL demonstrated favorable short-term refractive accuracy and binocular functional intermediate visual outcomes, with minimal dysphotopsia and no glistenings detected at 3 months.
Abstract
Purpose To evaluate short-term refractive outcomes, binocular defocus curves, visual phenomena, and intraocular lens (IOL) power calculation accuracy following implantation of the Clareon® monofocal (CNA0T0) IOL. Methods This was a prospective, single-arm clinical study. The study enrolled consecutive patients without prior ocular surgery or significant ocular pathology. All eyes underwent phacoemulsification and implantation of a CNA0T0 IOL. Primary endpoints were binocular distance and intermediate visual acuity; secondary endpoints included refractive accuracy, binocular defocus curves, visual phenomena, and IOL glistenings. Outcomes were measured up to 3 months postoperatively-sufficient to assess early refractive stability. Results Fifty participants (90 eyes) were enrolled, and 44 participants (88 eyes) completed the study. At 3 months, binocular distance-corrected defocus curves demonstrated favorable intermediate visual performance, with a mean visual acuity of 0.10 logMAR at −1.50 D (66 cm) and 0.30 logMAR at −2.50 D (40 cm). Dysphotopsias were infrequent, no IOL glistenings were observed on slit-lamp or SD-OCT examination during the 3-month follow-up, and cystoid macular edema occurred in 3 eyes (3.4%) at 1 month. The mean spherical equivalent at 3 months was −0.25 ± 0.38 D in myopic eyes, −0.09 ± 0.44 D in emmetropic eyes, and −0.10 ± 0.42 D in hyperopic eyes, with 82–85% of eyes within ±0.50 D of the target refraction. Conclusions The CNA0T0 IOL demonstrated favorable short-term refractive accuracy and binocular functional intermediate visual outcomes, with minimal dysphotopsia and no glistenings detected at 3 months. The Barrett Universal II and Hoffer QST formulas provided accurate refractive predictions across refractive subgroups in this cohort.
This segmental multifocal intraocular lens provides good visual acuity at all distances, particularly providing good intermediate visual acuity and depth of focus, and showed good contrast sensitivity and high spectacle independence with a high degree of patient satisfaction.
T. Kohnen, Jakob Wend, Zubeida H. Omerovic et al.· Journal of refractive surger...· 0 citations
PURPOSE
To evaluate visual, refractive, and quality-of-vision outcomes after unilateral cataract surgery or refractive lens exchange (RLE) with implantation of a rotationally asymmetric refractive multifocal intraocular lens (IOL), including the LENTIS Mplus LS-313 MF30 and LENTIS MplusX.
METHODS
Thirty-nine patients who underwent unilateral lens extraction (24 for cataract, 15 for RLE) with LENTIS Mplus multifocal IOL implantation were analyzed. Examinations were performed preoperatively and postoperatively at 1, 3, and 6 months, and at the final follow-up. Distance, intermediate, and near visual acuity, refraction, wavefront aberrations, contrast sensitivity, defocus curves, and Quality of Vision questionnaire scores were assessed.
RESULTS
At the final visit, 60.72 ± 37.75 months postoperatively, mean uncorrected and corrected distance visual acuity were 0.10 ± 0.23 and 0.01 ± 0.08 logMAR, respectively. Mean uncorrected and corrected near visual acuity were 0.10 ± 0.11 and 0.09 ± 0.17 logMAR, respectively. Mean uncorrected intermediate, corrected distance intermediate, and corrected distance near visual acuity were 0.12 ± 0.14, 0.12 ± 0.07, and 0.12 ± 0.15 logMAR, respectively. Defocus curves demonstrated broad functional vision across distance, intermediate, and near ranges. Contrast sensitivity and quality-of-vision outcomes suggested generally mild visual disturbances.
CONCLUSION
Unilateral implantation was well tolerated, with favorable monocular and binocular performance, high refractive predictability, and minimal optical side effects.
Hao Zhang, Alexander L Gonzales, Mario Cantó-Cerdán et al.· Seminars in Ophthalmology· 0 citations
The CNWTTx lens results in excellent visual acuities at distance, intermediate, and near, leading to high rates of spectacle independence and patients are subjectively satisfied with their visual outcomes.
Zachary Zavodni· Journal of Ophthalmology· 0 citations
Purpose To evaluate clinical outcomes in eyes with pre-existing astigmatism undergoing cataract surgery or refractive lens exchange with the implantation of an isofocal optic-design toric intraocular lens (IOL) with double C-loop haptics. Method This multicenter retrospective study comprised 100 eyes (65 patients) implanted with the Isopure Serenity toric IOL (BVI, Inc.) conducted across four sites. Postoperative evaluation at between 2 and 3 months included manifest refraction, monocular uncorrected and distance corrected visual acuity (UDVA and CDVA), monocular uncorrected and distance corrected intermediate visual acuity (UIVA and DCIVA, at 80 and 66 cm), monocular uncorrected and distance corrected near visual acuity (UNVA and DCNVA, at 40 cm), binocular defocus curve and rotational stability. Results Manifest refraction spherical equivalent and refractive astigmatism were −0.24±0.41D and −0.36±0.36D, respectively. About 79% and 97% of eyes were within ±0.50D and ±1.00D, respectively, and 80% and 96% of eyes were ≤0.50D and ≤1.00D of refractive cylinder, respectively. At distance vision, the mean monocular CDVA was −0.02±0.06 logMAR and 92.93% of eyes showed a CDVA of ≥20/20. At intermediate vision, the mean monocular DCIVA values were 0.10±0.07 and 0.17±0.10 logMAR at 80 cm and 66 cm, respectively; and 96.92% and 88.33% of eyes showed a DCIVA of ≥20/32 at 80 cm and 66 cm, respectively. At near vision, the mean monocular DCNVA was 0.31±0.08 logMAR and 75.44% of eyes showed a DCNVA of ≥20/40. The binocular depth of focus range was approximately 1.50D. The mean absolute IOL rotation was 2.73±2.58 degrees with all eyes having a rotation of <10 degrees. Conclusions Eyes with pre-existing astigmatism implanted with the Isopure Serenity toric IOL showed good distance visual acuity and functional intermediate vision, with high refractive accuracy and good rotational stability following cataract and refractive lens exchange surgery.
S. Daya, Takayuki Akahoshi, Camille Bosc et al.· Clinical Ophthalmology· 0 citations