The CRELD2-centered TLS-associated immune-inflammatory conceptual axis is pointed out, linking CRELD2 expression, endothelial/B-cell cellular contexts, B-cell-related immune infiltration, TLS-associated spatial localization, and recurrent TNFA/NFκB pathway enrichment via multi-omics and supporting it as a candidate therapeutic biomarker in ccRCC for further functional investigations.
Background: Clear cell renal cell carcinoma (ccRCC), the predominant histological subtype of kidney malignancies, is characterized by metabolic dysregulation and therapeutic resistance. Although the intracellular antioxidant paraoxonase 2 (PON2) is frequently dysregulated across multiple cancers, its biological role in...
Zhi-Yu Liu, Wei Yun, Ting Hong et al.· Cancers· 0 citations
Background The tumor immune microenvironment (TME) of diffuse large B-cell lymphoma (DLBCL) displays pronounced heterogeneity, and existing immunotherapeutic approaches achieve only suboptimal outcomes for a considerable proportion of affected individuals. CD161—a C-type lectin receptor whose coding gene is KLRB1—has l...
Er-Wei Li, Ying-Ying Tang, Yuanyuan Wanyan et al.· Frontiers in Molecular Biosc...· 0 citations
Although coiled-coil domain containing 69 (CCDC69) has been implicated in tumor biology, its role in triple-negative breast cancer (TNBC) and immune regulation remains unclear. Bulk transcriptomic data, single-cell RNA sequencing datasets, and spatial transcriptomics were used to investigate the role of CCDC69 in TNBC....
Jin-Jiao Li· Brazilian Journal of Medical...· 0 citations
Tetratricopeptide repeat domain protein 39B (TTC39B) is a lipid metabolism–related gene recently implicated in cholesterol regulation. However, its clinical and biological relevance in human cancers remains undefined.
Based on multi-omics data from the Cancer Genome Atlas (TCGA) pan-cancer dataset represen...
Hui-Juan Yi, Yan Wang, Chen-Hao Zhao et al.· BMC Medical Genomics· 0 citations
INTRODUCTION
SLC7A11 is part of the solute carrier family and encodes the transporter xCT. However, its functional role in renal cell carcinoma (RCC) progression and associated tumor microenvironment (TME) modulation remains poorly characterized and requires further investigation. This study aimed to explore SLC7A11 ex...
Xin-Yang Cheng, Jun Zhang, Ji-Xin Yuan et al.· Current Medicinal Chemistry· 0 citations
Cholangiocarcinoma (CHOL) is a highly heterogeneous and aggressive malignancy that is frequently diagnosed at an advanced stage because of the lack of early biomarkers, resulting in a poor prognosis. Although ANAPC1 overexpression has been reported in other cancers, its role and regulatory mechanisms in CHOL rema...
Ke-Jun Wu, Lei Wang, Yan-Ting Zhan et al.· Hereditas· 0 citations
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