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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

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Review Open access Aug 2026

Toward engineered microbial chassis for growth–production balancing

The inherent conflict between cellular growth and product synthesis, arising from limited resource allocation and metabolic burden, fundamentally constrains the performance of microbial chassis. Traditional strategies that focus solely on flux intensification or knockout of competing pathways often face diminishing ret...

Huang-Zhi Xia, Bingmei Wang, Feng Qi et al. · 1 citation
Open access Aug 2026

Dynamic Control of Prokaryotic Chromosome Ploidy Rewires Metabolic Networks to Enhance Product Biosynthesis

Building high-performance microbial cell factories requires dynamic coordination of resource allocation among cellular growth, target-product biosynthesis, and endogenous host metabolism. However, existing polyploid engineering strategies rely primarily on static manipulation of chromosome copy number. Although increas...

Xin Jin, Yaping Gao, Hannuo Shen et al. · 0 citations
Open access Sep 2026

Species-specific metabolic networks shape evolutionary routes to functional rescue

Metabolic networks are highly interconnected. Still, it remains unclear whether organism-and environment-specific factors shape their capacity to evolve in response to metabolic stress or whether it follows general principles. Here, we studied metabolic evolvability in Bacillus subtilis using auxotrophic mutants lackin...

Shanni Hornstein, Swati Sirotiya, Raul Mireles et al. · 0 citations
Review Sep 2026

Promoter Engineering in Yeast Cell Factories: Strategies, Applications, and Perspectives

Yeasts serve as premier eukaryotic hosts for microbial cell factories, enabling the production of recombinant proteins, biofuels, and high-value natural products. Precise transcriptional control is paramount for balancing complex metabolic pathways and maximizing target product yields. Promoters, as the key regulator...

Zhen-Zhen Bai, Tian Jiao, F. Darvishi et al. · 0 citations
Review Aug 2026

Metabolic engineering of Candida yeasts for biotechnological applications.

This review systematically summarize recent progress in the metabolic engineering of Candida species as microbial cell factories, with particular emphasis on expanding genetic toolkits, utilizting renewable and non-conventional carbon sources, and biosynthesizing high-value compounds.

Xin-Yue Li, Qi Wang, Hang-Ming Zhang et al. · 0 citations
Sep 2026

Programming 2,3-butanediol biosynthesis in Saccharomyces cerevisiae with AI-optimized dual-optogenetic switches.

Microbial cell factories promise sustainable biomanufacturing, yet balancing cellular growth and product synthesis remains a fundamental productivity bottleneck. While traditional static metabolic engineering fails to precisely orchestrate metabolic flux across temporal and spatial dimensions, optogenetic approaches of...

Sai-Nan Yang, Ren-Mei Liu, De-Chong Ou et al. · 0 citations

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