This review summarizes the general principles of ROS homeostasis, including regulatory circuit architecture, functional components and design strategies, and highlights recent advances, remaining challenges and potential solutions for engineering ROS-balanced microbial cell factories with improved robustness and production efficiency.
This review highlights the significant capacity of microalgae to produce a wide range of phenolic compounds and other secondary metabolites. It discusses the major abiotic stress factors affecting microalgal cells and their influence on secondary metabolite production and accumulation. Microalgae synthesize numerous bi...
W. A. Meshrf, M. Shallan, D. Marrez et al.· Stresses· 0 citations
In microbial cytoplasmic reaction compartments, competitive pathways and metabolic interactions often hinder the efficient synthesis of target compounds. In contrast, eukaryotic cells can control metabolic complexity by utilizing organelles to segregate biochemical pathways. Mitochondria, known as the “powerhouses of...
Jie Sheng, Xiao-Chun Zheng· ACS Synthetic Biology· 0 citations
The data indicate that APEs could act as a UPEC fitness factor, and in future work, it is aimed to study their contribution to overall bacterial pathogenicity and survival, as well as how APEs could facilitate the transition from an oxygen-poor environment, such as the gut, to the oxygen-rich environment of the urinary...
R. Markley, Isabel Johnston, V. Bobba et al.· Microbiology spectrum· 0 citations
These findings identify POA as an active metabolic modulator, not merely a passive structural lipid, pointing to a non-transgenic nutritional strategy whose industrial value now requires validation under high-gravity, pilot-scale, and serial-repatching conditions.
From the perspective of linking structural damage, oxidative stress and molecular regulation, this study clarified how antibiotic inhibited nitrogen metabolism in aerobic granular sludge (AGS). Long-term antibiotic stress severely damaged AGS structure, causing blurred boundaries, surface cracks and collapse zone. As a...
Wen-Hao Liu, R. Sun, He Wang et al.· Journal of Environmental Man...· 0 citations
Tryptophan-derived metabolites are indole-containing compounds with applications in medicine, functional foods, and agriculture. Conventional production via plant extraction or chemical synthesis is often inefficient and unsustainable, prompting the development of microbial biosynthesis. In this review, these metabolit...
Chen-Xi Qiu, Hong-Wei Guo, Quan-Pu Ren et al.· Journal of Agricultural and...· 0 citations
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