Histological and radiographic evaluation of bone formation following alveolar ridge preservation using octacalcium phosphate collagen composite: A prospective non-randomized controlled clinical trial
ARP using OCP/Col resulted in increased buccal bone height and enhanced bone maturation at the alveolar crest compared with atelocollagen alone, and may facilitate minimally invasive, prosthetically driven implant therapy.
Abstract
To radiographically and histologically evaluate bone formation following alveolar ridge preservation (ARP) using octacalcium phosphate collagen composite (OCP/Col). A total of 42 patients (48 sites) completed the study. The primary comparison was performed between an OCP/Col-treated molar group (OCP-M) and an atelocollagen-treated molar control group (Control-M). In addition, an OCP/Col-treated incisor–premolar group (OCP-IP) was included as an exploratory subgroup to assess tooth-type effects. Alveolar bone dimensional changes were assessed using cone-beam computed tomography (CBCT) immediately after ARP and at 6 months. Guided hard tissue biopsies were performed to quantify the proportions of mature bone and residual granules. Changes in buccal bone height were + 0.7 mm (± 2.2) in the OCP-M group, − 0.6 mm (± 0.7) in the Control-M group, and + 3.7 mm (± 3.9) in the OCP-IP group. The difference between the OCP-M and Control-M groups was significant (p = 0.041), as was that between the OCP-IP and OCP-M groups (p = 0.038). Histologically, the proportion of mature bone in the alveolar crest region was significantly higher in the OCP-M group (38.14% ± 20.96) than in the Control-M group (18.28% ± 16.52, p = 0.009). Within the limitations of this study, ARP using OCP/Col resulted in increased buccal bone height and enhanced bone maturation at the alveolar crest compared with atelocollagen alone. OCP/Col may serve as a stand-alone graft material for ARP and may facilitate minimally invasive, prosthetically driven implant therapy. UMIN000059637 (UMIN Clinical Trials Registry).
Within the limitations of this study, intentionally exposing the xenogeneic collagen matrix seal yielded comparable outcomes in non-contained and contained sockets, which may reflect the material's ability to reduce the adverse effects of socket-wall resorption.
Xinyi Zhou, Yuping Hong, Yang Yang et al.· Journal of Periodontal & Imp...· 0 citations
Maton's Trichrome staining may improve discrimination between osteoid/collagen matrix and mineralized tissue interfaces during histomorphometric analysis during histomorphometric analysis.
K. Gabel, B. Mealey, Michael P. Mills et al.· The Journal of Periodontolog...· 0 citations
Abstract The aim of this study was to evaluate the effect of autologous platelet-rich plasma (PRP) gel combined with nanohydroxyapatite (HA) on bone regeneration in critical-sized diaphyseal defects in rabbits. Fourteen clinically healthy adult New Zealand White rabbits were divided into two groups: control (HA only, n=7) and experimental (HA+PRP, n=7). Standardized defects were created in the radius (≥1.5× bone diameter), and radiological, histological, histochemical, and immunohistochemical analyses were performed on days 30, 60, and 90 post-surgery. Radiographically, the PRP group demonstrated earlier bone bridge formation and complete defect filling by day 90, with significantly higher healing coefficients (0.64 vs 0.21; p<0.05). Histological evaluation revealed accelerated callus maturation and active osteogenesis with organized bone marrow in the PRP group, whereas the HA group showed incomplete union and persistent fibrous tissue. Immunohistochemical staining (CD34) confirmed neovascularization and hematopoietic precursor cell proliferation in the PRP-treated defects. The combined use of nanohydroxyapatite and PRP gel significantly enhanced osteoregeneration and shortened healing time in critical-sized bone defects.
Georgi Marinov Marinov, N. Zlateva-Panayotova, Vesela Ivanova Todorova· Macedonian Veterinary Review· 0 citations
3D-printed β-TCP biomaterials demonstrated favourable clinical and radiographic outcomes for alveolar ridge regeneration supporting single implant rehabilitation and may provide a predictable alternative for localized alveolar ridge regeneration supporting single implant rehabilitation.
Carlo Mangano, Henriette Lerner, A. Aksu et al.· E -journal of dentistry· 0 citations
STA significantly increased STT but did not prevent buccal bone remodelling, and both augmentation approaches were associated with increased STT compared with no augmentation.
Louiza Papantonatou, L. Batas, A. Delantoni et al.· Journal of Clinical Periodon...· 0 citations
Unicameral bone cysts (UBCs) are fluid-filled, osteolytic lesions commonly affecting children and adolescents. Minimally invasive treatments such as percutaneous injection have become increasingly popular. Calcium phosphate cement (CPC), a biocompatible artificial bone substitute with mechanical strength and osteoconductivity, and may be suitable for such applications. This study aimed to evaluate the mid- to long-term clinical and radiographic outcomes of percutaneous calcium phosphate cement injection for UBCs, with particular emphasis on late recurrence, repeat injection, cortical remodeling, and cavity filling.
A retrospective review was conducted on 31 patients with UBC treated by CPC injection between January 2013 and January 2025, with at least 1 year of follow-up. Postoperative outcomes were assessed radiographically, functionally, and for complications. We recorded the patients’ age, sex, preoperative and postoperative visual analog scale (VAS) scores, Musculoskeletal Tumor Society (MSTS) scores, modified Neer classification and Capanna classification, cortical thickness ratio, cavity filling, recurrence, repeat intervention, and complications.
The mean follow-up duration was 61.1 months (range, 13–149 months). Among them, 14 patients experienced pathological fractures. Postoperatively, pain and functional outcomes improved significantly, with the median VAS score decreasing to 0 and the median MSTS score improving to 30 at final follow-up (
P
< 0.001). Recurrence after the first injection occurred in four patients (12.9%). Among them, three patients underwent repeat percutaneous CPC injection, and one patient was managed with observation because of adequate cortical thickness and clinical stability. At final follow-up after all treatments, all patients achieved modified Neer grade I or II outcomes, and most patients achieved Capanna grade I or II healing. One patient experienced delayed wound healing, and no severe complications were observed.
Percutaneous CPC injection was associated with pain relief, functional improvement, and radiographic stabilization in patients with UBCs. Repeat CPC injection appeared to provide stable outcomes in recurrent cases, whereas observation was considered reasonable for one clinically stable lesion with adequate cortical thickness. The observed cortical remodeling and cavity filling suggest that CPC injection may represent a potential minimally invasive strategy for reconstruction of UBC-related bone defects.
Meng-Zhang Xie, Zhengxiao Lai, Yi Luo et al.· Frontiers in Surgery· 0 citations
