CliniCIRCA is the first to temporally classify clinical events across unstructured discharge summaries without event-level timestamps and instruction tuning generally improves five open-weight models on event extraction, temporal tagging, and summarization across silver and clinician-verified evaluations.
Abstract
In mental health care, reasoning over patient journeys is a key task for clinicians. Yet these journeys, encompassing a longitudinal progression of biological, psychological, and social events, are often spread across disparate unstructured text narratives, making temporal recovery challenging. We present CliniCIRCA, a multi-stage LLM framework for Calendar-anchored, Imprecision-aware Reconstruction of Clinical Annals. To our knowledge, CliniCIRCA is the first to temporally classify clinical events across unstructured discharge summaries without event-level timestamps. From 14,882 MIMIC-III mental health admissions, we first construct a benchmark of 52 discharge summaries on which CliniCIRCA produces 15,891 temporally tagged events. After correcting 629 errors based on a clinician-in-the-loop evaluation, we produce verified gold-standard labels. Finally, the corrected timelines drive a temporally grounded summarization stage that compresses each source 1.52 times into a date-grouped chronological record. We then scale the framework to generate 1,000 silver-standard timelines and evaluate them as training data. Compared with zero- and few-shot prompting, instruction tuning generally improves five open-weight models on event extraction, temporal tagging, and summarization across silver and clinician-verified evaluations.
This work proposes CRAFT, an LLM framework that pairs a generator with a constraint-based verifier to iteratively produce and refine stage-wise symptom timelines through targeted feedback, and demonstrates that CRAFT consistently improves temporal ordering accuracy.
Chengyang He, Tahreem Arif, Marko Zivkovic et al.· 0 citations
Most electronic health record (EHR) data reside in unstructured text, recorded in encounters between health care providers and patients. These encounters capture symptom narratives, adverse effects, treatment rationales, adherence challenges, family history and other nuances that are not coded or only partially reflect...
Edward Kim, Richard Foty, A. Thakor et al.· Nature Medicine· 0 citations
Structured electronic health records (EHRs) contain a patient's clinical trajectory as a sequence of clinical codes. Answering clinical questions from such records requires both the context of the whole trajectory and the specific events that support the answer. We introduce GLoC-EHR, a multimodal language model that r...
Experimental results show that the proposed GuardMLLM improves performance on tasks such as predicting patient mortality and ICU length of stay, and effectively alleviates overconfidence in LLM.
Gang Fu, Xiao-Long Xu, Hao-Long Xiang et al.· IEEE journal of biomedical a...· 0 citations
Abstract Background Large language models (LLMs) are increasingly demonstrating the potential to reach human-level performance in generating clinical summaries from patient-clinician conversations. LLMs are usually evaluated against clinical summaries that focus mainly on patients’ biology and not on their biography (e...
Maria Lizarazo Jimenez, A. Claros, Kieran Green et al.· Journal of Medical Internet...· 0 citations
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