A unified framework for the LISA 2026 Challenge that performs all three tasks together within one inference pipeline, and addresses the scarcity of dense annotations using diffeomorphic registration from atlas to target for label propagation and to regularize anatomical reconstruction.
Abstract
Automated quality assessment, enhancement, and segmentation of multiple structures in $0.064\,\mathrm{T}$ ultra-low-field pediatric MRI are limited by a low signal-to-noise ratio, weak anatomical boundaries, and frequent artifacts. We present a unified framework for the LISA 2026 Challenge that performs all three tasks together within one inference pipeline. A network with two coupled streams, built on a 3D U-Net, first reconstructs an enhanced uLF volume and then combines the original and enhanced images for subcortical segmentation. To improve boundary stability, we add an auxiliary class covering brain tissue outside the target structures, derived from whole brain masks. A head conditioned on an artifact graph predicts the seven artifact ratings from reconstruction residuals and frozen segmentation features. We address the scarcity of dense annotations using diffeomorphic registration from atlas to target for label propagation and to regularize anatomical reconstruction. We report validation results across all three tasks.
Portable ultra-low-field (ULF) MRI can expand access to pediatric neuroimaging, but segmentation at 0.064 T remains challenging because anatomical boundaries are weakly delineated, small structures may be only partially visible, and high-field references can be locally misregistered. The LISA 2026 Challenge provides tw...
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