Synthesis, Antibacterial Evaluation, and Molecular Docking Investigations of Biologically Active Substituted Tetrazole-Linked 1,8-Naphthyridine Derivatives

Synthesis, Structure, and Antimicrobial Activity of Tetrahydrochromeno[2,3-d]pyrimidine Derivatives

Novel thiazolo[5,4-b]pyridine–sulfonamide conjugates: Synthesis, structure–activity relationship, and molecular docking studies

It is suggested that thiazolo[5,4-b]pyridine–sulfonamide hybrids represent promising scaffolds for the development of new antimicrobial agents.

Design and Synthesis of Novel Pyrazole-1,3,4-thiadiazine-Isoxazole Hybrids as Potent Antibacterial and Antibiofilm Agents: An Integrated In Vitro and In Silico Study

Pyrazole-1,3,4-thiadiazine-linked isoxazole derivatives, specifically 6n and 6o, are identified as potential candidates for the development of novel antibacterial and antibiofilm drugs.

Exploration of Novel Thiazole Scaffolds with Potential Therapeutic Applications

Compounds S6 and S1 showed the highest activity, possibly due to the thiazole nucleus linked to furan and substituted aromatic rings, and the experimental findings were consistent with the in silico molecular docking results.

Rational design, synthesis, and antimicrobial evaluation of novel 1,2,3-triazole hybrids: structure–activity relationships, molecular docking, and DFT studies

The results suggest that the 2,4-dichlorophenyl–1,2,3-triazole scaffold represents a promising starting point for further optimization, with antimicrobial activity governed by a balance between electronic properties and physicochemical factors influencing membrane permeability.

Synthesis of New Indole-Pyrazole linked Isoxazoles as Potent Antibacterial and Antibiofilm Agents

A series of new indole-pyrazole-linked isoxazole hybrids (5a-o) were synthesized using Cu(I)-catalyzed 1,3-dipolar cycloaddition and assessed for antibacterial and antibiofilm activities against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resista...