Dexmedetomidine Alleviates Cardiomyocyte Senescence Induced by Ischemia-Reperfusion Injury via Inhibiting the MDH2/NF-κB Pathway.

Bisdemethoxycurcumin Alleviates Myocardial Ischemia/Reperfusion Injury by AMPK-mediated Autophagy Activation and Apoptosis Suppression.

Myocardial ischemia/reperfusion (I/R) injury impairs the prognosis of patients with cardiovascular disease. Reperfusion induces cardiomyocyte apoptosis and dysregulates autophagy, thereby disrupting cellular homeostasis and exacerbating myocardial injury. Bisdemethoxycurcumin (BDMC), a major active component of Curcuma...

Kisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis

Endothelial cell-derived MYDGF alleviates cardiomyocyte injury in rats after ischemia/reperfusion.

INTRODUCTION Crosstalk in the heart is essential for normal cardiac development and disease progression. We explored the potential cardioprotective effects of endothelial cell-derived myeloid-derived growth factor (MYDGF) on the myocardium during ischemia/reperfusion (I/R) injury. METHODS Rat H9C2 cardiomyocytes and...

Knockdown of VNN1 protects cardiac myoblasts from hypoxia/reoxygenation injury via the PI3K/Akt pathway.

Myocardial ischemia/reperfusion (I/R) injury is a critical factor contributing to adverse outcomes following infarction, primarily due to oxidative stress, inflammation, and cardiomyocyte death. Vanin-1 (VNN1), a pantetheinase enzyme involved in redox regulation, has recently emerged as a potential mediator of tissue d...

Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis

Remimazolam (RMZ) is an ultra-short-acting sedative anesthetic that provides protection against cerebral and hepatic ischemia/reperfusion injury. However, its potential cardioprotective effect in myocardial ischemia reperfusion injury (MIRI) remains to be fully elucidated. The present study investigated the hypothesis...

Eucalyptol Mitigates Isoproterenol-Induced Myocardial Injury in Rats via Activation of p38 MAPK/JNK Signaling, Suppression of ER Stress, and Modulation of Apoptotic Pathway.

1,8-cineole exhibits potent cardio-protection in experimental myocardial injury by targeting inflammation, apoptosis, ER stress, and oxidative stress through modulation of p38 MAPK/JNK, suppression of inflammatory markers, and enhanced Nrf2 nuclear translocation and subsequent upregulation of antioxidant enzymes are id...