Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Similar papers

Open access Aug 2026

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Extracellular targeted protein degradation (eTPD) systems typically utilize lysosome-targeting receptors (LTRs) to mediate internalization and lysosomal degradation of extracellular and membrane proteins. While multiple LTRs have been discovered, there remains a compelling need to seek for new LTRs, particularly those...

Lu Chen, Xin-Ying Fu, Wen-Qian Dong et al. · 0 citations
Review Open access Sep 2026

Molecular design and delivery of extracellular and membrane protein degradation chimeras.

This Review provides a framework for selecting disease-matched degradation routes and advancing meTPDs from platform-specific demonstrations towards predictable therapeutic modalities by integrating molecular design, receptor biology, intracellular trafficking, delivery and pharmacodynamic considerations.

Shu-Tong Lin, Hui-Ling Zhou, Jia-Yan Qiu et al. · 0 citations
Aug 2026

Caged Glycan-Antibody Conjugates for Tumor-Selective Activation of Lysosome-Targeting Chimeras.

A chemically activatable LYTAC platform that leverages tumor microenvironment-specific cues to achieve precise and safe protein degradation in vivo is reported, significantly enhancing the safety and therapeutic window of lysosome-targeted degradation strategies in cancer therapy.

Mohan Chen, Yi-Cun Li, Xue-Ting Wei et al. · 0 citations
Aug 2026

Expanding the Repertoire of Lysosomal Degradation of Membrane Proteins: A Generalizable Strategy Using Multivalent Antibody−Polymer Chimeras

It is posited here that multivalent noncovalent interactions can trigger endosomal uptake and lysosomal degradation of specific membrane proteins in combination with an ancillary membrane protein, where the ancillary protein does not need to possess endogenous lysosome-directing characteristics.

Ranit Dutta, Yasin Alp, Prachi Gupta et al. · 1 citation
Sep 2026

Modular Lysosome-Targeting Platform Based on a Multivalent DNA Framework for Programmable Protein Degradation.

Targeted degradation of extracellular and membrane-bound proteins holds immense therapeutic potential but remains technically challenging. Lysosome-targeting chimeras (LYTACs) have emerged to bridge this gap, yet platforms built on monomeric aptamers suffer from inadequate stability, inefficient cellular uptake, and a...

Xin Wan, Quan-Hao Dou, Jia-Lin Zeng et al. · 0 citations
Aug 2026

Dissecting PROTAB-mediated degradation of cell surface proteins.

It is shown that PROTAB induces rapid ternary complex formation, followed by receptor internalization and degradation, resulting in ~ 85% target depletion within 24 h, and mechanistically, ubiquitination enhances but is not strictly required for internalization, and degradation proceeds predominantly through the lysoso...

Jieyan He, Tao Sun, Mengwen Zhang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.