TL;DR
This review discusses current breakthroughs in aptamer and peptide functionalized microfluidic biosensors for exosome-based cancer diagnostics, focusing on their translation into POC applications, and highlights present challenges, as well as potential future prospects.
Exosomes are nano-sized extracellular vesicles secreted by cells and they have emerged as promising biomarkers for non-invasive clinical diagnostics. However, their small size (30–200 nm) and low abundance in biofluids pose significant challenges for isolation and detection. This review highlights recent advances in el...
This work highlights strategies specifically designed for epithelial-mesenchymal transition (EMT)-associated CTC phenotypes and explores AI- and IoT-enabled implementations for decentralized oncology, and a comprehensive evaluation of electrochemical approaches for CTC and ctDNA detection.
This review summarizes relevant biosensor types, including electrochemical, optical, mass-sensitive, microfluidic, nano-biosensors (recently developed), and hydrogel-based systems with discussion of their underlying analytical principles and performance for clinically important cancer biomarkers.
A microfluidic SERS platform integrating plasmonic nanobowl arrays that simultaneously achieve a high enhancement factor and signal reproducibility and provides a promising tool for EV-based precision oncology.
This review provides a comprehensive overview of the latest advancements and current trends in nano-biosensor technology as a promising tool in cancer diagnostics.
The functional roles of representative nanomaterials in pathogen POCT, including optical signal output, catalytic signal amplification, target enrichment, and interfacial regulation are summarized, and their applications in respiratory, urinary, and fecal specimens are discussed.
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