Surgery for Drug Resistant Epilepsy with Malformations of Cortical Development: Role of Non-Invasive Pre-Surgical Evaluation, Surgical Strategy and Seizure Outcome Prediction.

M. B. Rao Ajinkya Rewatkar A. Asranna B. Bhaskarapillai A. Arimappamagan Ravindu Tiwari K. Kulanthaivelu L. G. Vishwanathan Jitender Chaturvedi G. Sandeep N. Sadashiva R. Chowdary A. Mahadevan R. Kenchaiah Jitender Saini R. Bharath Sandhya Mangalore J. Rajeswaran P. Satishchandra S. Sinha

Sep 2026 · Neurology India · Vol 74 5, pp. 877-884 · 0 citations

Medicine

TL;DR

It is found that factors such as fewer anti-seizure medications and complete resection of the lesion were associated with a favorable outcome on multivariable analysis and should not per se exclude patients with MCD from undergoing epilepsy surgery.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Open access Aug 2026

Surgical Selection in Drug-Resistant Epilepsy: A Contemporary Evidence-Based Review of Patient Stratification, Presurgical Evaluation, and Surgical Outcomes

Continued advances in imaging, electrophysiology, minimally invasive techniques, and neuromodulation are transforming the management of DRE and facilitating increasingly individualized treatment strategies.

Vartika Gupta, Pankaj Gupta · Asian Journal of Neurosurger... · 0 citations

Review Sep 2026

Expedited epilepsy surgery for patients seen in a first seizure clinic.

INTRODUCTION First seizure evaluation clinics (FSCs) provide rapid, specialized assessment of patients with a suspected new-onset seizure. Their role in identifying patients who may benefit from epilepsy surgery has not been well described. We evaluated the frequency, timing, and outcomes of epilepsy surgery among pati...

Cody L. Nathan, Stephen VanHaerents, Michael C. Oblich et al. · Epilepsy & Behavior · 0 citations

Open access Sep 2026

Non-invasive preoperative prediction of surgical outcomes in drug-resistant epilepsy using seizure-related EEG network dynamics

Stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation (RF-TC) has emerged as a minimally invasive treatment option for selected patients with drug-resistant epilepsy (DRE). However, its overall therapeutic efficacy remains suboptimal, with seizure-free rates typically falling below 70%. To facilit...

R. Feng, Q. Luo, Dan-Ni Yang et al. · Frontiers in Neuroscience · 0 citations

Open access Aug 2026

Variability in recommending epilepsy surgery across Level IV epilepsy centers in the United States.

Similar children evaluated at different institutions had significant differences in the odds of not being recommended surgery, suggesting that institutional decision-making contributes importantly to surgical candidacy.

A. Caraway, Nancy A. Mcnamara, Andrew T. Knox et al. · Epilepsia · 0 citations

Review Open access Sep 2026

Postoperative outcomes and predictors of functional sequelae following hemispheric surgery in Rasmussen's encephalitis: A retrospective cohort study from the global pediatric epilepsy surgery registry.

Hemispheric disconnection in pediatric RE yields high rates of seizure freedom and caregiver-perceived QoL improvement but carries substantial risks of motor, language, and visual sequelae.

Krish Nair, N. Benjamin, E. Harford et al. · Epileptic disorders · 0 citations

Open access Sep 2026

Outcomes of Stereoelectroencephalography-Guided Surgery in Patients with Drug-Resistant Epilepsy: A Single-Center Study

SEEG appears to be an effective, safe, and minimally invasive evaluation modality for pediatric DRE, associated with favorable seizure outcomes even in complex, deep-seated, multilobar, or non-lesional cases, supporting its role as a valuable alternative to subdural grid-based intracranial monitoring.

Shi-Liang Jang, Hui-Jin Shin, Se Hee Kim et al. · Annals of Child Neurology · 0 citations