Review: The African turquoise killifish as a model for the integrative physiology of vertebrate aging.

Aging in Spaceflight, Oxidative Stress, and Microbiome Dysbiosis: A Comprehensive Review

Examination of evidence surrounding mitochondrial dysfunction, oxidative stress, and gut microbiome dysbiosis across humans, mice, and fruit flies under spaceflight and corresponding terrestrial control conditions finds that biomarker genes most associated with mutation accumulation and antagonistic pleiotropy appear t...

Exploring Astyanax mexicanus as a model for unraveling genotype-environment interactions and metabolic adaptations.

Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans

A framework for understanding microbial contributions to aging is offered and potential directions for future research aimed at extending healthspan in higher organisms are highlighted.

Conditional Senescence and Longevity Mechanisms in Early-Branching Metazoans: Insights from Hydra

Organismal aging is not inevitable in multicellular animals, as early-branching metazoan lineages, such as cnidarians, display negligible senescence under defined conditions, despite conserved cellular pathways. Contrasting longevity phenotypes in Hydra species reveal distinct regulatory mechanisms underlying aging. A...

to aging in the regeneration-capable

It is proposed that M. lignano represents a novel powerful model for molecular studies of aging attenuation, and the identified aging gene expression patterns provide a valuable resource for further exploration of anti-aging strategies.

Stress responses and dynamic equilibrium: key determinants of ageing in the Caenorhabditis elegans clk-1 mutant

A health index based on the attrition of neuromuscular behaviours to assess the health of various strains is introduced and suggests that while stress responses may enhance lifespan, overall health is determined by the extent of the damage.