Integration of methylome and transcriptome reveals age-associated signatures of stage-specific dynamics and regulatory remodeling in dogs.

Heterogeneous epigenetic regulatory patterns link mammalian aging, development, and mortality

Analysis of DNA methylation in mammalian blood reveals fundamental links between epigenetic regulation during development, aging, and chronic diseases and develops epigenetic clocks that predict expected mortality across species and tissues and are effective in detecting a range of disease models.

Replicative history as a major determinant of epigenetic noise across human tissues

DNA methylation changes accumulate with age through both regulated and stochastic processes, yet the determinants of epigenetic information loss remain poorly defined. Using genome-wide DNA methylation profiles from 1,531 healthy human samples spanning 14 tissues, we quantified epigenetic noise by Shannon entropy and c...

A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease.

Epigenetic aging is a hallmark of chronic diseases. While such epigenetic changes can arise following tissue injury, the cell types most affected remain largely unknown. Here we built a cross-species single-cell multiomics atlas of DNA methylation, chromatin accessibility and transcription profiles from healthy, injure...

Single-cell transcriptomic and epigenomic analysis reveals X-linked sex differences in aging mouse hypothalamus

Evolutionary Epigenetic Analysis of Oxidative Balance Score-Associated DNA Methylation Sites Across Mammals

Oxidative Balance Score (OBS) summarizes diet- and lifestyle-related exposures relevant to redox homeostasis, but the evolutionary behavior of OBS-associated epigenetic markers remains unclear. In this study, we conducted a covariate-adjusted epigenome-wide association study (EWAS) in Korean Genome and Epidemiology Stu...

Conserved Partial Reprogramming Effects on the Methylome

Background/Objectives: Among the many proposed theories of aging, a growing body of research points to epigenetic alterations, particularly changes in DNA methylation patterns, as key contributors to biological decline. DNA methylation can be targeted and modulated to induce anti-aging and regenerative effects using an...