Aug 2026· Journal of Human Genetics· 0 citations· 211 references
Medicine
TL;DR
This review summarizes the diagnostic, prognostic, predictive, and therapeutic potential of tissue-derived, circulating, and exosomal miRNAs in NSCLC and discusses the major challenges limiting the clinical translation of miRNA-based biomarkers and therapeutics.
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, largely due to late diagnosis, molecular diversity, and frequent development of treatment resistance. MicroRNAs (miRNAs) play critical roles in NSCLC initiation, progression, and treatment resistance. Previous studies have ide...
Maryam Abdipourbozorgbaghi, R. Radpour, S. Haefliger· Cancer Cell International· 0 citations
The complexity of KRAS biology in NSCLC is highlighted and the importance of integrating molecular, epigenetic, and therapeutic insights to advance precision medicine and improve clinical outcomes is underscored.
Jadwiga Gaździcka, K. Gołąbek· International Journal of Mol...· 0 citations
A review of recent advances in understanding the regulatory role of ncRNAs on the PD-1/ PD-L1 pathway in brain cancer tumorigenesis highlights promising opportunities for developing therapeutic interventions against brain cancer.
Reihane Behnam-Rassouli, Farzaneh Entezari, Majid Ghorbanzadeh et al.· Iranian Journal of Basic Med...· 0 citations
Background Neoadjuvant chemoimmunotherapy is standard care for resectable non-small cell lung cancer (NSCLC), yet 70% to 80% of patients do not achieve a pathologic complete response, and no validated biomarker identifies likely non-responders before or during treatment. Circulating microRNAs (miRNAs) have been propose...
I. Augustin, Adelina Birceanu, L. Mazilu et al.· The journal of liquid biopsy· 0 citations
Non-coding RNAs (ncRNAs) in tumor-educated platelets (TEPs) play an important role in cancer progression. Tumor cells can “educate” platelets, thereby enabling them to participate in multiple stages of tumor development and progression. The ncRNAs carried by TEPs, including microRNAs (miRNAs), circular RNAs (circRNAs),...
Ya-Ning Liu, Yu-Cheng Zhang, Dong-Ni Li et al.· Frontiers in Oncology· 0 citations
Overall, this review provides an updated perspective on the potential of miRNAs in DLBCL and outlines key challenges and future directions for their integration into precision oncology, as miRNAs can remodel the clinical management of DLBCL by enabling earlier diagnosis, improved prognostication, and personalized treat...
Corina Joldes, Laura Jimbu, O. Mesaros et al.· Biomedicines· 0 citations
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