Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers
Aug 2026· Neurotoxicity research· Vol 44· 0 citations· 79 references
Medicine
TL;DR
Results support modulation of the Nrf2/KEAP1 pathway as a mechanism contributing to the neuroprotective actions of Met and identify the coordinated enhancement of antioxidant defenses and reduction of lipid peroxidation as key components of neuronal redox resilience against AβOs-induced stress.
Computer analyses supported its Keap1-targeting activity, identifying CS-11 as a promising Parkinson’s disease therapeutic candidate and showing the strongest neuroprotective effect in a Parkinson’s disease model.
P. Deshmukh, Snehal U. Aouti, Ashok Sridhar et al.· ACS Medicinal Chemistry Lett...· 0 citations
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid‑beta (Aβ) plaques and associated oxidative and inflammatory neurotoxicity. Carotenoids are being investigated as promising nutritional candidates that may attenuate Aβ‑induced damage through multiple parallel mechanisms, including reducing oxidati...
Juanita Mathews· International Journal for Vi...· 0 citations
JP1 acts as a promising coordinator of antioxidant and autophagic processes by targeting the Keap1-Nrf2-ARE pathway, thus highlighting its therapeutic potential for ALS.
Yu Zhang, Yaxi Liu, Shiyu Shi et al.· BMC Medicine· 0 citations
Oxidative stress is a key pathological feature of Alzheimer's disease (AD), characterized by increased levels of reactive oxygen species (ROS), malondialdehyde (MDA), 4-hydroxynonenal, and protein carbonyls, alongside impaired antioxidant defenses such as superoxide dismutase (SOD). These alterations contribute to endo...
BACKGROUND
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide and the leading cause of dementia. Mitochondrial dysfunction is a key pathogenic event that drives neuronal damage and disease progression. Thus, protecting against mitochondrial damage in neuronal cells has become a critical th...
Jun Cai, Jing Luo, Yong-Gui Cai et al.· Cellular Signalling· 0 citations
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) accumulation and oxidative stress, with aging being its greatest risk factor. Age-related glutathione (GSH) depletion may increase neuronal vulnerability to Aβ toxicity, but the underlying mechanisms remain unclear. Her...
Kazi Rafsan Radeen, Cai-Li Hao, Zong-Bo Wei et al.· Free Radical Biology & Medic...· 0 citations
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