Aug 2026· npj Digital Medicine· Vol 9· 3 citations· 171 references
Medicine
TL;DR
This structured, integrative overview shows that theoretical and empirical work identify various hypothetical and observed harms associated with the use of LLM chatbots in mental health.
Abstract
Chatbots based on large language models (LLMs) are increasingly used in everyday life. Although concerns about negative impacts on mental health are raised, a synthesis of the research and themes of the growing field of potential mental health harms of LLM-based chatbots has not yet been conducted. For the present scoping review, a PRISMA-based systematic literature search with a validated search string was conducted, identifying N = 3137 articles from five literature databases (ACM, IEEE, PubMed, Science.gov, Google Scholar) and a supplementary search. N = 119 articles were included that (1) focus on LLM-based chatbots, and (2) focus on the harms of use on mental health. Literature was divided into five categories. Conceptual works mention harms based on chatbot limitations (hallucinations, sycophancy, bias), data security issues, and risks for severe or high-risk psychiatric cases (e.g., suicide, psychosis). Vignette studies show that LLM-based chatbots respond inappropriately to mental health queries compared with clinical standards. Cognitive overreliance on chatbots is associated with decreased cognitive and academic performance. Problematic use of LLM-based chatbots, marked by symptoms of emotional or social dependency and withdrawal, correlates with mental health symptoms. Articles on AI psychosis propose several potential links between delusional beliefs and LLM-based chatbot use, such as risks of chatbots reinforcing and validating delusional beliefs. This structured, integrative overview shows that theoretical and empirical work identify various hypothetical and observed harms associated with the use of LLM chatbots in mental health.
Background
During the COVID-19 pandemic, the use of mental health chatbots received potential attention as a means of addressing the increase in demand for mental healthcare, which has become inaccessible due to a shortage of healthcare workers and lockdown. Even after the pandemic, chatbot versatility holds the potent...
Khanh Dang Bao Tieu, Felix Agyapong-Opoku, B. Agyapong· Frontiers in Digital Health· 0 citations
Mental health disorders impose a substantial global burden, while access to care remains constrained. AI-based chatbots have emerged as scalable digital interventions, yet existing evidence is limited by heterogeneous intervention types and methodological shortcomings. This study aimed to evaluate the effects of AI-bas...
Qi-Yi Wang, Jia-Le Zhong, Kai Qi et al.· Psychiatry Research· 0 citations
BACKGROUND
Loneliness is widespread globally, especially among older adults. Chatbots based on natural language processing (NLP) have demonstrated unique potential for alleviating this problem because of their high accessibility, low cost, and spatiotemporal flexibility; however, systematic reviews that comprehensively...
Jia-Lin Wang, Xue Wang, Xiaorong Dong et al.· Journal of the American Medi...· 0 citations
In this self-selected convenience sample, AI-chatbot-associated harms were frequently described in relation to delusional beliefs, perceived chatbot validation, intensive use, and substantial social, occupational, and clinical consequences.
H. Morrin, Vinitha Soundararajan, Thomas Cheliotis-James et al.· 0 citations
Empirical studies of LLM-enabled AI chatbot applications and evaluations for health purposes across four stakeholder groups: the public or patients, health professionals, health researchers and students, and health institutions are mapped.
Yuan Wang, Romy Rw, Yan-Jiao Deng et al.· Frontiers in Public Health· 0 citations
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