Higher expression of all six lncRNAs in gastric cancer was associated with unfavourable overall survival and co-expression enrichment identified several cancer-associated pathways, most prominently epithelial–mesenchymal transition.
It is suggested that UPK1A-AS1 is a hypoxia‐inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type‐dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia‐associated drug resistance in HCC.
Ze-Kai Li, Min Luo, Shu-Sen Fang et al.· Analytical Cellular Patholog...· 0 citations
This computational study identifies several candidate lncRNAs associated with clinical outcomes in breast cancer, which should be interpreted as preliminary candidates, which require future validation and functional studies to determine their biological roles and evaluate their potential as prognostic biomarkers.
M. Acencio, Xin-Hui Wang, Flavia R. Rotea Mangone et al.· International Journal of Mol...· 0 citations
This study found that LINC02257 and LINC00659 are upregulated in BC and are associated with malignancy-related genes and patient survival, suggesting their potential as therapeutic targets and prognostic biomarkers.
Fatemeh Badzohre, Azin Azadfekr, Farnoosh Akbari et al.· Current Genetic Medicine Rep...· 0 citations
The established eight-ARlncRNA signature serves as a robust prognostic tool, effectively predicting patient survival and mirroring the heterogeneity of the tumor immune landscape, and offers potential guidance for personalizing therapeutic strategies in glioma.
Yuting Ouyang, Rui Han, An-Qi Song et al.· Discover Oncology· 0 citations
A robust G2/M -associated regulatory framework in LUAD is defined, characterized by reciprocal dysregulation of oncogenes and tumor suppressors and associated with the predicted TMPO-AS1–hsa-let-7b-5p regulatory network, which is linked to a less immunosuppressive tumor microenvironment, offering potential prognostic a...
The developed risk model offers valuable insights for clinical prognostic prediction and immunotherapy in KIRC and indicates an increased likelihood of immune escape in the high-risk group.
Shi-Bin Guo, Shuangqin Xu, Peng Song et al.· Medicine· 0 citations
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