TL;DR
A native Type I-F CRISPR-mediated precise genome editing technique is introduced that enables in situ alanine substitutions in MexB in clinical MDR P. aeruginosa genotypes to facilitate the development of effective EPIs.
Multidrug efflux pumps are a critical mechanism underlying both intrinsic and acquired resistance in Acinetobacter baumannii. One of the most perilous multidrug-resistant (MDR) bacterial infections. Resistance-nodulation-division transporters, including AdeABC, AdeIJK, and AdeFGH, are critical efflux systems that dimin...
ABSTRACT Coagulase-negative staphylococci (CoNS) are common inhabitants of healthcare environments and can serve as reservoirs of antimicrobial resistance determinants. However, the relationship among disinfectant tolerance, efflux-associated phenotypes, and multidrug resistance in environmental CoNS remains incomplete...
Multidrug-resistant (MDR) Gram-negative bacteria—particularly carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa and Acinetobacter baumannii—remain among the hardest infections to treat, and Resistance-Nodulation-Division (RND) efflux pumps are central to that resistance, making them a recurring target for a...
Background Abuse of β-lactam antibiotics and its spread of drug resistance challenged the applicability of antimicrobial agents, enabling polymyxins as a last-line treatment for anti-infections of multi-drug resistant (MDR) pathogen. Polymyxin is applicable to herb breeding/growth prompting and combatting Gram-negative...
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