Optimization of fermentation parameters and mutagenesis of Glarea lozoyensis ATCC 20868 towards pneumocandin B0 production

Enhanced production of phomapyrrolidone a through culture-condition optimization and morphological regulation in Didymella sp. FATR0054

Phomapyrrolidone A (Ppd A) is a hirsutellone-type macrocyclic alkaloid derived from marine fungi, exhibiting significant activity against triple-negative breast cancer (TNBC). However, its low fermentation yield has limited further drug development. This study established a systematic optimization strategy integrating...

Optimisation of fermentation conditions for cell growth of recombinant Lactococcus lactis ATCC11454-ldhΔnisRKOE using response surface methodology

Food safety and shelf-life preservation remain major challenges in agroindustry due to the increasing prevalence of foodborne pathogens and the growing demand for natural alternatives to synthetic preservatives. Recombinant lactic acid bacteria capable of producing antimicrobial peptides have emerged as promising candi...

A novel route for valerolactam production in Corynebacterium glutamicum: metabolic engineering and bioprocess optimization

Optimization of α‐Amylase Production on Raw Substrates in Haloalkaliphilic Actinobacteria, Nocardiopsis alba Kam‐13 by Statistical Approaches

The use of low‐cost agricultural and food‐processing waste materials as substrates can reduce enzyme production costs and contribute to the sustainable management and valorization of waste. This work describes the optimization of α‐amylase production by the haloalkaliphilic actinobacterium Nocardiopsis alba Kam‐1...

Enhanced Astaxanthin Production in Rhodosporidium toruloides via Sequential Benomyl-EMS Mutagenesis and Culture Medium Optimization

An effective strategy for improving astaxanthin biosynthesis is demonstrated and the industrial potential of BE1 for natural astaxanthin production is highlighted, demonstrating an effective strategy for improving astaxanthin biosynthesis.

Development of a Whole-Cell Bioprocess for Ursodeoxycholic Acid Production from Lithocholic Acid Using Fusarium equiseti HG18

Ursodeoxycholic acid (UDCA) is the first-line therapy for primary biliary cholangitis and an important active constituent of bear bile. Whole-cell microbial conversion of inexpensive lithocholic acid (LCA) offers a promising alternative to conventional chemical synthesis owing to its high regioselectivity and mild reac...