TL;DR
A combined density functional theory (DFT) with experimental study have been performed for the physico-chemical characterization of the inclusion complexes of β-cyclodextrin with painkillers belonging to the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) group, suggesting robustness under physiologically relevant conditions.
β-Cyclodextrin (β-CD) inclusion complexes are widely employed to improve the physicochemical properties of poorly soluble drugs; however, the molecular factors governing their stability and binding affinity remain insufficiently understood. In this study, the complexation of β-CD with two β2-agonists, salbutamol (SAL...
Fluoroquinolones (ciprofloxacin and levofloxacin) are broad-spectrum antibiotics, but their use is limited by low solubility, toxicity, and the risk of resistance. The use of cyclodextrins and polymeric carriers is a promising approach to overcome these limitations. In this work, we systematically studied the complexat...
Xenon (Xe) is an inert noble gas receiving increasing attention in medical research due to its anesthetic properties, ability to regulate metabolic processes, and broad organoprotective effects. Due to its small size and non-covalent intermolecular interactions, Xe can be encapsulated within α-cyclodextrin (α-CD). In t...
Isatin‐based ligands have been recognized for their remarkable pharmacological potential and this study reports the synthesis, characterization, and biological evaluation of three novel nickel(II)‐isatin hydrazone complexes ( C1–C3 ). The complexes were characterized by FT‐IR, UV–vis, mass spectroscopy, DFT, magn...
This study investigated the synthesis and pharmacological properties of chromium metal complexes with sulfonylureas (hypoglycemic agents). In these complexes, the structural element (chromium) is held within the cavity of the β-cyclodextrin (βCD) molecule. Conditions were optimized for the inclusion complex: 1:1 host...
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