Borate‐Crosslinked Bioadhesives With Double Network Fabricated Using Dopamine‐Conjugated Gelatin and Polyvinyl Alcohol Incorporating Catechin Acid: Potential in Biomedical Applications
Jul 2026· Polymer Engineering & Science· 0 citations· 55 references
TL;DR
Rheological characterization confirmed typical viscoelastic solid behavior, favorable injectability, and excellent self‐healing capability, the latter of which was also supported by macroscopic observations.
Abstract
The hydrogel bio‐adhesive has demonstrated outstanding potential in regenerative wound care. Here, we prepared borate‐crosslinked bioadhesive hydrogels (PPGB) composed of dopamine‐conjugated gelatin (Gel‐DA), polyvinyl alcohol (PVA), and catechin acid. Scanning electron microscopy revealed an interconnected porous microstructure within the PPGB matrix. Rheological characterization confirmed typical viscoelastic solid behavior, favorable injectability, and excellent self‐healing capability, the latter of which was also supported by macroscopic observations. Antioxidant activity was validated through ABTS and DPPH radical scavenging assays. The PPGB adhesives exhibited strong adhesion to various material surfaces and moist organic tissues. Antibacterial testing demonstrated efficient activity against the typical Gram‐positive and Gram‐negative bacteria. Biocompatibility evaluation using CCK‐8 assays and DAPI/phalloidin staining of NIH 3 T3 fibroblasts exposed to hydrogel extracts indicated good cytocompatibility. Furthermore, a scratch wound healing assay confirmed enhanced cell migration. Collectively, these findings present a straightforward strategy for engineering multifunctional hydrogel bio‐adhesives with potential for biomedical applications.
A polyacrylic acid/polyvinyl alcohol composite hydrogel fabricated via self‐catalyzed free radical polymerization, with borax serving as the reinforcing phase, achieves synergistic antibacterial and intelligent responsive therapeutic performances, providing a reliable and high‐efficiency candidate for advanced wound care and next‐generation wound dressing applications.
Lin-Han Hu, Zheng Yang, Xinwei Tao et al.· Macromolecular Bioscience· 0 citations
Hemolysis assays and cytocompatibility evaluations confirmed the favorable hemocompatibility of the HTP hydrogels, which significantly promoted fibroblast proliferation and migration, indicating their substantial potential for wound healing applications.
Lei Nie, Xinran Li, Mengfei Feng et al.· International Journal of Bio...· 0 citations
Background/Objectives: Tissue bio-adhesives have gained significant attention as efficient alternatives to conventional wound closures, which are often hindered by insufficient adhesion and poor biocompatibility. Methods: Inspired by nature’s robust wet-adhesion strategies that use dynamic covalent interactions, we have reported a facilely fabricated hydrogel bio-adhesive based on lactobionic acid-conjugated polyethylenimine (LA-PEI) and oxidized dextran (ODex) via Schiff base linkages. Results: The prepared hydrogels exhibited three-dimensional interconnected porous networks, regulated swelling ratios, typical viscoelasticity, shear-thinning behavior, and self-healing ability. Notably, the swelling ratios of the hydrogels depended on composition, and OLP11 displayed the highest swelling ratio of over 1500%. The hydrogel bio-adhesives exhibited strong adhesion to various surfaces, including glass, metal, plastic, rubber, and wood, as well as to different chicken organs, including the heart, liver, spleen, and stomach. Furthermore, the hydrogels exhibited excellent ABTS radical-scavenging activity, effective intracellular reactive oxygen species (ROS) scavenging, and good hemocompatibility, with hemolysis ratios of all hydrogels close to 0%, below the threshold of 5%. After culturing with NIH 3T3 fibroblasts, the hydrogels demonstrated good cytocompatibility and promoted cell proliferation, with cell viabilities on day 3 reaching over 90%. Conclusions: This design yields multifunctional hydrogel bio-adhesives, showing strong promise for wound care and tissue repair applications.
Lei Nie, Xiao-Ran Hu, Shichang Cheng et al.· Pharmaceutics· 1 citation
This work presents a mechanically robust, highly efficient, and exceptionally safe light-activated platform for advanced wound dressing applications and demonstrates strict biosafety without collateral phototoxicity.
A multifunctional composite hydrogel (GelDA/OPL) with excellent adhesion, self-healing properties, injectability, and photothermal antibacterial activity through Schiff base crosslinking between dopamine-modified gelatin (GelDA) and oxidized pullulan (OPL) is constructed.
Chen Zhang, Surui Yang, Zhi Xu et al.· Journal of materials chemist...· 0 citations
It is demonstrated that the catechol-nanocellulose/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.
