Sep 2026· Medical Oncology· Vol 43· 0 citations· 70 references
Medicine
TL;DR
Overall, this review provides a comprehensive overview of the design, synthesis, functionalization, therapeutic applications, pharmacokinetics, biodistribution, safety profiles, and clinical translation potential of folate-functionalized chitosan NPs for precision cancer therapy.
Background: Systemic toxicity, poor drug selectivity, treatment resistance, and inconsistent tumor responses are some of the therapeutic issues related to thyroid cancer (TC). Chitosan-based nanoparticles (ChNPs) have shown promise as nanocarriers for target drug delivery due to their mucoadhesive qualities, biodegrada...
Recent advances in the field of nanotechnology have accelerated the development
of polymeric nanocarriers for cancer therapy, enabling high precision and improved
therapeutic efficiency. Among these, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs)
have gained significant attention, as PLGA is a U.S. FDA-ap...
Madhusudan Maity, Niranjan Panda, Subas C. Dinda et al.· Recent Patents on Nanotechno...· 0 citations
This review provides an overview of nanoparticle-based targeted drug delivery in cancer therapy, with emphasis on passive and active targeting mechanisms, major nanoparticle platforms, therapeutic applications, current challenges, and prospects for clinical translation.
G. Patil, Kartik Parmar, Kavita Rana· Journal of Drug Delivery and...· 0 citations
Polysaccharide-based colon-targeted drug delivery systems provide safer, more effective, and more personalized treatment with continued research to optimize delivery and overcome existing limitations.
Tan-Wan Yi, Pankaj Kumar, R. Karwasra et al.· Journal of Visualized Experi...· 0 citations
Tamoxifen remains a cornerstone in the treatment of estrogen receptor-positive breast cancer, yet its clinical performance is limited by poor aqueous solubility, high lipophilicity, and interindividual variability associated with CYP2D6-mediated formation of its more potent active metabolites. These challenges necessit...
In conclusion, while nanocarriers offer significant advancements in targeted cancer therapy, their successful clinical implementation depends on overcoming various scientific, technical, and regulatory challenges.
Busayo Olamide Tomoh· International Journal of Med...· 0 citations
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