TL;DR
This chapter offers a comprehensive, reproducible protocol for identifying and clinically validating circulating long noncoding RNA (lncRNA) biomarkers for NAFLD and NASH.
This computational study suggests that fecal CE(20:4) and the associated COX-2 pathway may represent candidate features of a CRC-like metabolic state in colorectal adenomas.
Background: Fibrosis development in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progression, but interstudy heterogeneity and li...
These findings bridge the gap between metabolic lipotoxicity and epigenetic regulation, suggesting that lactylation acts as a critical driver in NAFLD pathogenesis.
Metabolic dysfunction-associated steatotic liver disease (MASLD), the leading cause of chronic liver pathologies worldwide, represents a growing clinical burden. Its diagnosis remains reliant on liver biopsy that limits early detection and the ability to capture molecular changes across disease progression. A systemati...
Genetically proxied plasma RARRES1 is associated with increased LCINS risk and may contribute to disease susceptibility through immune-related alterations involving NKT-cell phenotypes, providing biologically plausible evidence supporting a role for RARRES1 in LCINS pathogenesis and its potential utility in biomarker d...
Nephrolithiasis and obesity are common and recurrent public health problems, yet current obesity-based risk assessment does not identify which individuals are most susceptible to stone formation. We sought circulating markers linked to obesity-related stone susceptibility and risk heterogeneity rather than a diagnost...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
