It is shown that safe clinical deployment of LLM-based chatbots requires governance addressing accuracy, interpretability, and masking of poorer performance by conversational fluency, and the divergence between user preference and measured accuracy underscores that safe clinical deployment of LLM-based chatbots requires governance addressing accuracy, interpretability, and masking of poorer performance by conversational fluency.
Abstract
Background Chatbots are increasingly used in healthcare for symptom checking and care navigation. However, concerns about accuracy limit large language model (LLM) use in clinical settings. Objective This convergent mixed-methods study evaluated three enhancements to an existing rules-based triage chatbot. The purpose is to inform the development of tools improving patient access and system navigation. Methods Three artificial intelligence tools (Dialogflow, ChatGPT, and Gemini) were integrated into a rules-based workflow from December 21st 2024 to July 7th 2025. Thirteen testers completed 156 vignette-based interactions and 52 Likert-scale evaluations from July 17th 2025 to August 5th 2025. Quantitative outcomes included accuracy, conversational turns, time to completion, and tester ratings. Qualitative feedback was thematically analyzed. Results The rules-based chatbot was most accurate (71.8%, 95% CI 56.2–83.5%), outperforming Dialogflow (30.8%, p = 0.002) and Gemini (41.0%, p = 0.031). Dialogflow, ChatGPT, and Gemini were statistically indistinguishable. Qualitative analysis revealed user preference for ChatGPT and Gemini despite equal or worse performance than the rules-based chatbot. Conclusion Rules-based triage remained most reliable, and the divergence between user preference and measured accuracy underscores that safe clinical deployment of LLM-based chatbots requires governance addressing accuracy, interpretability, and masking of poorer performance by conversational fluency.
Highlights What are the main findings? Instrument-based information-quality scores differed among the tested chatbot configurations, but these differences do not establish greater factual accuracy, guideline concordance, or clinical superiority; the full-set DISCERN comparison was limited because most questions were no...
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