The VGLUT3-p.T8I Mutation Alters Striatal Acetylcholine Dynamics in Response to Social Stressors and Drives Selective Social Avoidance in Male Mice

Cocaine disrupts stress resilience through state-dependent dopaminergic mechanisms in the nucleus accumbens.

BACKGROUND Depression and substance use disorders frequently co-occur, yet it remains unclear whether similar depression-related behaviors reflect a common underlying neural state. Cocaine use is associated with worsening depressive symptoms, suggesting that drug exposure may interact with pre-existing behavioral state...

Microglia sculpt dopamine receptor-mediated adolescent behaviors in a social experience dependent manner

The role of oxytocin receptors in social conditioned place preference.

Investigating the neural mechanisms underlying social reward is important not only to further current understanding of adaptive social behaviors, but also for informing potential therapeutic strategies for disorders associated with impaired social functioning. A growing body of literature indicates that the neuropeptid...

Hippocampal Cc2d1a/Freud-1 Knockdown Alters Serotonin and Dopamine Systems and Depressive-Like Behavior in ASC (Antidepressants Sensitive Catalepsy) Male Mice.

Brain monoamine systems regulate a wide spectrum of behaviors. Serotonin (5-HT) is traditionally linked to depression, whereas dopamine (DA) is associated with anhedonia and impaired motivation. The genes for the 5-HT1A receptor (Htr1a) and DRD2 receptor (Drd2) share a common transcription factor, Freud-1, encoded by C...

Psilocybin restores social novelty investigation in male SAPAP3 knockout mice and engages prefrontal-hippocampal circuitry.

It is demonstrated that psilocybin exerts domain-specific, enduring effects on social cognition in an established model of compulsive-like behavior, potentially involving prefrontal plasticity-related mechanisms.

Activation of D2-Expressing Medium Spiny Neurons in the Nucleus Accumbens Core Mirrors the Delaying Effect of Novelty Exposure on Feeding Onset in Rats

These findings suggest that NAcc D2-MSNs are recruited under conditions of environmental novelty to modulate feeding-related decision-making, and may impair behavioral flexibility and contribute to maladaptive feeding patterns, with implications for the neurobiology of eating disorders.