Tumor resistance to protein kinase inhibitors.

Breast Cancer CDK4/6 Inhibitor Resistance and Immunotherapy Strategies

Two main ways in which CDK4/6 inhibitors exert their effects are reviewed, one is to directly block the cell cycle, and the other is to reshape the immune microenvironment.

From receptor biology to therapy: importance of different EGFR mutations in the development of targeted cancer therapies.

Cancer is a leading cause of death globally, and traditional therapies including chemotherapy and radiotherapy are often constrained by systemic toxicity and lack of specificity. Thus, targeted therapies are the need of the hour to revolutionize cancer treatment by enhancing specificity and selectivity, and minimizing...

Targeting KRAS in Cancer: Advances in Precision Oncology and Drug Development

These breakthroughs have validated direct KRAS inhibition as an effective therapeutic strategy, however, durable clinical responses remain limited by intrinsic and acquired resistance, pathway reactivation, tumour heterogeneity, and the lack of effective therapies for non-G12C KRAS mutations.

Targeting the Ubiquitin-Proteasome System: An Emerging Paradigm for Overcoming Resistance to Targeted Therapy in Non-Small Cell Lung Cancer.

The molecular mechanisms by which the UPS contributes to targeted therapy resistance in NSCLC are summarized, recent progress in emerging UPS-targeting strategies are evaluated, and the major barriers impeding their clinical translation are critically discussed.

Mechanisms of resistance to PARP inhibitors in advanced epithelial ovarian cancer: biological determinants and therapeutic implications

PARP inhibitors have become an integral component of treatment strategies for advanced epithelial ovarian cancer, particularly in BRCA1/2-mutated and homologous recombination-deficient (HRD) tumors. Despite clinically meaningful improvements in progression-free survival, a substantial proportion of patients develop pri...

Researchers find novel mechanism of resistance to anti-cancer drugs