Identification of Genome-Wide Chromatin Structural Aberration in Cancer by Hi-C Analysis.

Analysis of Chromatin Structure Using Network Approaches: A Step-by-Step Guide.

Recurrent deletions and regulatory disruption of the Y chromosome in cancer

Somatic loss of the Y chromosome (LOY) is the most frequent acquired genomic alteration in aging males and occurs across multiple cancer types. While common, its functional role in tumorigenesis is only beginning to emerge. Most studies treat LOY as a binary event, ignoring partial deletions that may selectively remove...

Spatial chromatin architecture and accessibility co-profiling of mammalian tissues.

Cellular function depends on the spatial organization of cells and biomolecules within the tissue microenvironment. Advances in spatial omics have enabled profiling of molecular features such as transcriptome, proteome and epigenome, and there has been rapid progress of imaging-based approaches to study spatial three-d...

Evolution, application and clinical significance of profiling chromatin interactions at a genome-wide scale.

Over the past few decades, chromatin biology has evolved from viewing chromatin as a static structural scaffold to decoding it as a dynamic, programmable regulatory landscape. At the heart of this transformation is the precise mapping of interactions between functional proteins and cognate DNA elements. Although high-t...

CUT&Tag for Chromatin Profiling in Cancer Tissue.

LAWS-HiC: A Locally Adaptive Weighting and Screening (LAWS) Approach to Improve Detection of Long-Range Chromatin Interactions from Hi-C Data

Hi-C technologies are widely used to study genome-wide chromosome spatial organization. Among various Hi-C data analyses, detecting long-range chromatin interactions (i.e., 3D peak calling) is particularly critical due to its direct relevance to gene regulation. However, most existing peak callers fail to account for s...