Pyrrocidines and hirsutellones: distinctive fungal polyketide alkaloid hybrids with intriguing therapeutic applications: a comprehensive update.

Latest developments of spirooxindoles and their derivatives in medicinal chemistry.

This study summarizes recent developments in spirooxindole-containing compounds, both naturally isolated and synthetically prepared, reported in the last few years.

Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances.

Covering: 2002-2025Marine fungi have emerged as a prolific source of structurally unprecedented and biologically potent secondary metabolites, and hybrid polyketide synthase-non-ribosomal peptide synthase (PKS-NRPS) enzymes mainly from marine fungi like symbiotic Aspergillus and deep-sea Penicillium, represent an excep...

Erinacerins from Hericium erinaceus: a review of their chemistry, bioactivities, and NMR characterization.

The Epoxybenzooxocine Core of Integrastatins and Analogs: A Comprehensive Review of Structure, Synthetic Approaches, and Biological Applications

Integrastatins and their biogenetic counterparts possess a rare heterotetracyclic framework containing an unprecedented [6/6/6/6]-tetracyclic skeleton and a central [3/3/1]-bicyclic ketal core with high pharmaceutical potential, particularly due to their potent anti-HIV-1 integrase activity. Despite their promising sca...

Sponge Derived Macrolides (2000-2023): Chemical Diversity, Mechanistic Insights and Therapeutic Potential.

This narrative mini-review covers the period from 2000 to 2023, focusing on the chemical, mechanistic insights, and therapeutic potential of 96 novel macrolides isolated from marine sponge species, showing promising in vivo antitumor efficacy and enhanced pharmacokinetic profiles.

Monoterpenoids from Artemisia porrecta Krasch. ex Poljakov and their anti-inflammatory and antibacterial activities.

This work focused on investigating the chemical constituents of the plant Artemisia porrecta Krasch. ex Poljakov, resulting in the isolation and characterization of twenty-one monoterpenes. Eight previously undescribed compounds and one new natural product were isolated, including three pairs of enantiomers. All known...