Advances in the Enzymic Synthesis of Unnatural Chiral Amino Acids.

Application and progress of synthetic biology technology in amino acid production

Advances in the Biosynthesis of Noncanonical Amino Acids for Genetic Code Expansion.

Recent advances in fully autonomous ncAA biosynthesis for GCE technology across microbial, zebrafish, and mammalian systems are summarized and emerging applications of these biosynthetic strategies in biological research and therapeutic development are highlighted.

Nitrene generation and transfer for unnatural biosynthesis in living cells.

It is shown that chemical reactions of metabolic intermediates produced intracellularly in living cells can include intermolecular nitrene transfers.

Recent trends in synthetic approaches to α-amino ketones.

The α-amino ketone motif is fundamentally important in both synthetic organic and medicinal chemistry due to its frequent occurrence in biologically active molecules and its versatility as a building block in drug discovery. This significance has spurred the development of numerous innovative synthetic methodologies ov...

A pyridoxal phosphate-dependent enzyme platform for stereoselective synthesis of γ-tertiary-nitro-noncanonical amino acids

Non-canonical amino acids (ncAAs) are privileged building blocks for the synthesis of natural products, biocatalysts, and drug molecules. Among them, γ-tertiary-nitro-α-amino acids are highly valuable yet remain scarcely explored due to challenges in synthetic accessibility. Although pyridoxal-5′-phosphate (PLP)-depend...

Manipulating activity and chemoselectivity of a benzaldehyde lyase to synthesize α-hydroxyketones.